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Tbio
IER3
Radiation-inducible immediate-early gene IEX-1

Protein Summary
Description
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259874
  • ENSP00000259874
  • ENSG00000137331
  • ENST00000383560
  • ENSP00000373054
  • ENSG00000206478
  • ENST00000416884
  • ENSP00000406245
  • ENSG00000227231
  • ENST00000435856
  • ENSP00000412283
  • ENSG00000235030
  • ENST00000439190
  • ENSP00000397956
  • ENSG00000237155
  • ENST00000450236
  • ENSP00000398139
  • ENSG00000230128

Symbol
  • DIF2
  • IEX1
  • PRG1
  • DIF2
  • IEX1
  • PRG1
  • DIF-2
  • GLY96
  • IEX-1
  • IEX-1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.97
gene perturbation
0.96
transcription factor binding site profile
0.91
small molecule perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.02   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.02   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.946
Data Source:  Reactome,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.945
Data Source:  Reactome,STRINGDB
PPP2R5C
Tbio
Family:  Enzyme
Novelty:  0.03336609
Score:  0.943
Data Source:  Reactome,STRINGDB
PPP2R5B
Tbio
Family:  Enzyme
Novelty:  0.08980945
Score:  0.942
Data Source:  Reactome,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.932
Data Source:  STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
Score:  0.902
Data Source:  STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
Score:  0.9
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.9
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.866
Data Source:  STRINGDB
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome
PIP3 activates AKT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PIP3 activates AKT signaling
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (150)
Items per page:
1 – 5 of 150
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
92.5
2
2
0
1.1
92.5
2
2
0
1.1
92.5
2
2
0
1.1
92.5
2
2
0
1.1
92.5
Items per page:
1 – 5 of 150
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immediate early response 3
VGNC:11097
462547
Macaque
immediate early response 3
701939
Mouse
MGI:104814
15937
Rat
RGD:1303321
294235
Horse
immediate early response 3
VGNC:18942
100055430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immediate early response 3
Macaque
immediate early response 3
Mouse
Rat
Horse
immediate early response 3
Publication Statistics
PubMed Score 159.02
PubMed score by year
PubTator Score 81.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title