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Tchem
BDKRB1
B1 bradykinin receptor

Protein Summary
Description
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216629
  • ENSP00000216629
  • ENSG00000100739
  • ENST00000611804
  • ENSP00000479276

Symbol
  • BRADYB1
  • B1R
  • BKR1
  • B1BKR
  • BKB1R
  • BDKRB2
  • BRADYB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.9
gene perturbation
0.82
biological process
0.81
virus perturbation
0.72
biological term
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.92   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.92   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 613
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
icatibant
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Active Ligands (613)
1 – 10 of 613
CHEMBL487445
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CHEMBL412824
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CHEMBL408846
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CHEMBL3085458
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CHEMBL3142391
Rendered image for CHEMBL3142391
CHEMBL413775
Rendered image for CHEMBL413775
chroman 28
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CHEMBL189123
Rendered image for CHEMBL189123
CHEMBL299164
Rendered image for CHEMBL299164
Protein-Protein Interactions (364)
1 – 10 of 364
KNG1
Tbio
Novelty:  0.00007684
Score:  0.992
Data Source:  Reactome,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.955
Data Source:  STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.944
Data Source:  STRINGDB
BDKRB2
Tclin
Family:  GPCR
Novelty:  0.00335227
Score:  0.938
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.931
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.928
Data Source:  STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
Score:  0.925
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.923
Data Source:  STRINGDB
NMB
Tbio
Novelty:  0.00729571
Score:  0.921
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.919
Data Source:  STRINGDB
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
subcutaneous adipose tissue measurement
1
1
0
232.2
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
subcutaneous adipose tissue measurement
0
232.2
0
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bradykinin receptor B1
VGNC:12987
100612769
Macaque
bradykinin receptor B1
712251
Mouse
MGI:88144
12061
Rat
RGD:620401
81509
Dog
bradykinin receptor B1
VGNC:38424
490847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bradykinin receptor B1
Macaque
bradykinin receptor B1
Mouse
Rat
Dog
bradykinin receptor B1
Publication Statistics
PubMed Score 187.92
PubMed score by year
PubTator Score 261.48
PubTator score by year
Patents
Patents by year