Tbio ASMT Acetylserotonin O-methyltransferase

Protein Summary

Description

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P46597
• B2RC33
• Q16598
• Q5JQ72
• Q5JQ73

Gene Name

• ASMT

Ensembl ID

• ENST00000381229
• ENSP00000370627
• ENSG00000196433
• ENST00000381233
• ENSP00000370631
• ENST00000381241
• ENSP00000370639

Symbol

• ASMTY
• HIOMT
• HIOMTY

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
tissue	0.63
protein domain	0.58
cell line	0.53
biological process	0.49

Protein Classes

DTO Classes

N-acetylserotonin O-methyltransferase-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.12   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.12   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0