You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASMT
Acetylserotonin O-methyltransferase

Protein Classes
Protein Summary
Description
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381229
  • ENSP00000370627
  • ENSG00000196433
  • ENST00000381233
  • ENSP00000370631
  • ENST00000381241
  • ENSP00000370639

Symbol
  • ASMTY
  • HIOMT
  • HIOMTY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
tissue
0.63
protein domain
0.58
cell line
0.53
biological process
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.96   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.96   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (44)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Serotonin and melatonin biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Serotonin and melatonin biosynthesis
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (54)
1 – 10 of 54
AANAT
Tbio
Family: Enzyme
Novelty: 0.0039709
Score: 0.992
Data Source: STRINGDB
IDO2
Tchem
Family: Enzyme
Novelty: 0.01141558
Score: 0.932
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.931
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.924
Data Source: STRINGDB
CYP1B1
Tchem
Novelty: 0.00090917
Score: 0.92
Data Source: STRINGDB
IDO1
Tchem
Family: Enzyme
Novelty: 0.00131229
Score: 0.915
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.913
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.908
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.906
Data Source: STRINGDB
ALDH1B1
Tbio
Family: Enzyme
Novelty: 0.01755208
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  420.96

PubMed score by year
PubTator Score  160.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer