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Tchem
NOTCH1
Neurogenic locus notch homolog protein 1

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or diff ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277541
  • ENSP00000277541
  • ENSG00000148400

Symbol
  • TAN1
  • hN1
  • AOS5
  • TAN1
  • AOVD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
1
protein domain
1
PubMedID
0.98
molecular function
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9562.48   (req: < 5)
Gene RIFs: 1102   (req: <= 3)
Antibodies: 1214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9562.48   (req: >= 5)
Gene RIFs: 1102   (req: > 3)
Antibodies: 1214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 154
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (928)
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.999999998
p_ni:  2e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.999999279
p_ni:  7.21e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999980151
p_ni:  0.000019809
p_wrong:  4e-8
Data Source:  BioPlex
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.999963247
p_ni:  0.000036694
p_wrong:  5.8e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999406616
p_ni:  0.000576514
p_wrong:  0.00001687
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.991732079
p_ni:  0.001457598
p_wrong:  0.006810323
Score:  0.257
Data Source:  BioPlex,STRINGDB
MAML1
Tbio
Novelty:  0.01302751
Score:  0.999
Data Source:  STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.999
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.999
Data Source:  STRINGDB
NUMB
Tbio
Novelty:  0.00211228
Score:  0.994
Data Source:  Reactome,STRINGDB
Pathways (87)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

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Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (168)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
4
6
90.6
neutrophil count
4
3
4
85.9
2
2
1
1.2
84.7
alkaline phosphatase measurement
2
2
1
8.9
83.1
leukocyte count
3
3
3
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
90.6
neutrophil count
4
85.9
1
1.2
84.7
alkaline phosphatase measurement
1
8.9
83.1
leukocyte count
3
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
notch 1
VGNC:4807
464865
Mouse
MGI:97363
18128
Rat
RGD:3187
25496
Dog
notch 1
VGNC:43898
480676
Horse
notch 1
VGNC:20817
100068764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
notch 1
Mouse
Rat
Dog
notch 1
Horse
notch 1
Publication Statistics
PubMed Score 9562.48
PubMed score by year
PubTator Score 1621.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title