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Tbio
CDKN1B
Cyclin-dependent kinase inhibitor 1B

Protein Summary
Description
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from qui ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228872
  • ENSP00000228872
  • ENSG00000111276

Symbol
  • KIP1
  • KIP1
  • MEN4
  • CDKN4
  • MEN1B
  • P27KIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.55   (req: < 5)
Gene RIFs: 759   (req: <= 3)
Antibodies: 2501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.55   (req: >= 5)
Gene RIFs: 759   (req: > 3)
Antibodies: 2501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
5
5
96.6
1
3
0
1.2
84
appendicular lean mass
3
2
3
78.7
myeloid white cell count
2
2
2
76.2
mosaic loss of chromosome Y measurement
2
2
3
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
96.6
0
1.2
84
appendicular lean mass
3
78.7
myeloid white cell count
2
76.2
mosaic loss of chromosome Y measurement
3
75.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 1B
VGNC:8367
466947
Macaque
cyclin dependent kinase inhibitor 1B
697188
Mouse
MGI:104565
12576
Rat
RGD:69062
83571
Dog
cyclin dependent kinase inhibitor 1B
VGNC:39069
403429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 1B
Macaque
cyclin dependent kinase inhibitor 1B
Mouse
Rat
Dog
cyclin dependent kinase inhibitor 1B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P46527-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (160)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular Senescence
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (376)
1 – 10 of 376
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
p_int:  0.99999993
p_ni:  7e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
CCND2
Tbio
Novelty:  0.00157305
p_int:  0.999995861
p_ni:  0.000004139
Score:  0.996
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999985552
p_ni:  0.000003491
p_wrong:  0.000010957
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.999940517
p_ni:  0.000059475
p_wrong:  8e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999925073
p_ni:  0.000074701
p_wrong:  2.26e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999900196
p_ni:  0.000099804
Score:  0.846
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999833293
p_ni:  0.000166703
p_wrong:  4e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
p_int:  0.998168939
p_ni:  0.001831061
Score:  0.964
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.997202751
p_ni:  0.002796675
p_wrong:  5.74e-7
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  1383.55

PubMed score by year
PubTator Score  1582.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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