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Tbio
NSF
Vesicle-fusing ATPase

Protein Summary
Description
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398238
  • ENSP00000381293
  • ENSG00000073969
  • ENST00000611398
  • ENSP00000478614
  • ENSG00000278174
  • ENST00000620290
  • ENSP00000481714
  • ENSG00000276262

Symbol
  • SKD2
  • SEC18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
protein domain
0.97
disease perturbation
0.87
biological process
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.22   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.22   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (339)
RBKS
Tbio
Family:  Kinase
Novelty:  0.01660806
p_int:  0.829898124
p_ni:  0.170101876
Score:  0.696
Data Source:  BioPlex,STRINGDB
SCFD1
Tbio
Novelty:  0.02924747
Score:  0.997
Data Source:  Reactome,STRINGDB
NAPA
Tbio
Novelty:  0.00618772
Score:  0.996
Data Source:  Reactome,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.993
Data Source:  Reactome,STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.991
Data Source:  Reactome,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.99
Data Source:  STRINGDB
NAPG
Tbio
Novelty:  0.02295985
Score:  0.989
Data Source:  STRINGDB
STX18
Tbio
Novelty:  0.0259034
Score:  0.989
Data Source:  Reactome,STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
Score:  0.987
Data Source:  Reactome,STRINGDB
GOSR2
Tbio
Novelty:  0.02447711
Score:  0.985
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
1 – 5 of 16
GABRA6
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRA4
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRB2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRA2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRG3
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (39)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (198)
Items per page:
1 – 5 of 198
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
10
6
6.9
96.1
neuroticism measurement
4
10
6
6.9
96.1
neuroticism measurement
4
10
6
6.9
96.1
Parkinson disease
2
2
0
1.3
93.7
Parkinson disease
2
2
0
1.3
93.7
Items per page:
1 – 5 of 198
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
6
6.9
96.1
neuroticism measurement
6
6.9
96.1
neuroticism measurement
6
6.9
96.1
Parkinson disease
0
1.3
93.7
Parkinson disease
0
1.3
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
VGNC:12577
107968982
Macaque
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
715297
Mouse
MGI:104560
18195
Rat
RGD:621594
60355
Dog
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
VGNC:43983
490921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Macaque
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Mouse
Rat
Dog
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Publication Statistics
PubMed Score 769.22
PubMed score by year
PubTator Score 991.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title