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Tbio
GSTM5
Glutathione S-transferase Mu 5

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256593
  • ENSP00000256593
  • ENSG00000134201

Symbol
  • GTM5
  • GSTM5-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
protein domain
0.73
kinase perturbation
0.71
gene perturbation
0.68
PubMedID
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.08   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.08   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
44.9
apolipoprotein A 1 measurement
1
1
1
25.9
high density lipoprotein cholesterol measurement
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
44.9
apolipoprotein A 1 measurement
1
25.9
high density lipoprotein cholesterol measurement
1
24.2
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase mu 5
VGNC:6852
745685
Anole lizard
glutathione S-transferase Mu 1
100554103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase mu 5
Anole lizard
glutathione S-transferase Mu 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46439-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (66)
1 – 10 of 66
GSTM2
Tchem
Family: Enzyme
Novelty: 0.00334543
p_int: 1
Score: 0.959
Data Source: BioPlex,STRINGDB
GSTM4
Tbio
Family: Enzyme
Novelty: 0.03845761
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
p_int: 0.999993572
p_ni: 0.000006428
Score: 0.939
Data Source: BioPlex,STRINGDB
ERLIN2
Tbio
Novelty: 0.04060163
p_int: 0.999404135
p_ni: 0.000595865
Score: 0.232
Data Source: BioPlex,STRINGDB
ARFGAP1
Tbio
Family: Enzyme
Novelty: 0.02654081
p_int: 0.989428158
p_ni: 0.010571842
Score: 0.269
Data Source: BioPlex,STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.902
Data Source: STRINGDB
GSTT2B
Tbio
Family: Enzyme
Novelty: 0.02334158
Score: 0.858
Data Source: STRINGDB
GSTO1
Tchem
Family: Enzyme
Novelty: 0.00800915
Score: 0.838
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.831
Data Source: STRINGDB
GSTA3
Tbio
Family: Enzyme
Novelty: 0.02008269
Score: 0.822
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.08

PubMed score by year
PubTator Score  13.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer