Tbio MTIF2 Translation initiation factor IF-2, mitochondrial

Protein Summary

Description

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P46199
• D6W5D0
• IF-2(Mt)

Gene Name

• MTIF2

Ensembl ID

• ENST00000263629
• ENSP00000263629
• ENSG00000085760
• ENST00000394600
• ENSP00000378099
• ENST00000403721
• ENSP00000384481

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
histone modification site profile	0.93
protein domain	0.92
disease perturbation	0.9
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Translation Initiation Factor If-2, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Translation Initiation Factor If-2, Mitochondrial

Protein / Hydrolase / Translation Initiation Factor If-2, Mitochondrial

Protein / Enzyme Modulator / G-protein / Translation Initiation Factor If-2, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Translation Initiation Factor If-2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.32   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.32   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0