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Tbio
CRKL
Crk-like protein

Protein Summary
Description
May mediate the transduction of intracellular signals. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354336
  • ENSP00000346300
  • ENSG00000099942
  • ENST00000411769
  • ENSP00000396646
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
interacting protein
0.94
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.95   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 678   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.95   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 678   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
74.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
74.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CRK like proto-oncogene, adaptor protein
VGNC:12833
107970369
Mouse
MGI:104686
12929
Rat
RGD:6493647
100911248
Dog
CRK like proto-oncogene, adaptor protein
VGNC:39619
608125
Horse
CRK like proto-oncogene, adaptor protein
VGNC:16869
100050855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CRK like proto-oncogene, adaptor protein
Mouse
Rat
Dog
CRK like proto-oncogene, adaptor protein
Horse
CRK like proto-oncogene, adaptor protein
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (74)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signal transduction
Reactome
Erythropoietin activates RAS
Reactome
Frs2-mediated activation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Downstream signal transduction
Erythropoietin activates RAS
Frs2-mediated activation
Immune System
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (258)
1 – 10 of 258
IFIT5
Tbio
Novelty: 0.03547542
p_int: 0.983447191
p_ni: 0.016552809
Score: 0.685
Data Source: BioPlex,STRINGDB
RAPGEF1
Tbio
Novelty: 0.00365765
Score: 0.997
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.995
Data Source: Reactome,STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.989
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.981
Data Source: STRINGDB
DOCK1
Tbio
Novelty: 0.00867391
Score: 0.98
Data Source: STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.98
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.979
Data Source: STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
Score: 0.978
Data Source: Reactome,STRINGDB
GAB1
Tbio
Novelty: 0.02174353
Score: 0.978
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  213.95

PubMed score by year
PubTator Score  130.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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