Tbio CRKL Crk-like protein

Protein Summary

Description

May mediate the transduction of intracellular signals. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• P46109
• A8KA44
• D3DX35

Gene Name

• CRKL

Ensembl ID

• ENST00000354336
• ENSP00000346300
• ENSG00000099942
• ENST00000411769
• ENSP00000396646

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.95
interacting protein	0.94
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
disease perturbation	0.87

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.88   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 678   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.88   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 678   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0