Protein Summary
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
- ENST00000300574
- ENSP00000300574
- ENSG00000167193
- ENST00000398970
- ENSP00000381942
- p38
- CRKII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.99 | ||
disease perturbation | 0.95 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
pathway | 0.85 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 404.84 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 571 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 404.84 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 571 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 1 | 1 | 82.7 | |||||
intraocular pressure measurement | 1 | 1 | 0 | 7.4 | 64 | ||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 29.9 | |||||
reticulocyte count | 2 | 1 | 2 | 24.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 17 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 82.7 | |||||
intraocular pressure measurement | 0 | 7.4 | 64 | ||||
lymphocyte percentage of leukocytes | 2 | 29.9 | |||||
reticulocyte count | 2 | 24.6 | |||||
self reported educational attainment | 1 | 17 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88508 | 12928 | ||||||
Rat | RGD:2405 | 54245 | ||||||
Dog | CRK proto-oncogene, adaptor protein | VGNC:54290 | 100684309 | |||||
Horse | CRK proto-oncogene, adaptor protein | VGNC:51791 | 100072356 | |||||
Cow | CRK proto-oncogene, adaptor protein | VGNC:27716 | 512841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | CRK proto-oncogene, adaptor protein | |||||
Horse | CRK proto-oncogene, adaptor protein | |||||
Cow | CRK proto-oncogene, adaptor protein | |||||
Protein Structure (10 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (103)
Reactome (32)
KEGG (18)
PathwayCommons (35)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 32
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ARMS-mediated activation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Downstream signal transduction | ||||
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ARMS-mediated activation | ||||
Cytokine Signaling in Immune system | ||||
Downstream signal transduction | ||||
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Hemostasis | ||||
Gene Ontology Terms (47)
Functions (11)
Components (8)
Processes (28)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (360)
1 – 10 of 360
RAPGEF1
Novelty: 0.00365765
Score: 0.998
Data Source: Reactome,STRINGDB
DOCK1
Novelty: 0.00867391
Score: 0.997
Data Source: Reactome,STRINGDB
BCAR1
Novelty: 0.00329214
Score: 0.996
Data Source: Reactome,STRINGDB
ABL1
Family: Kinase
Novelty: 0.00023803
Score: 0.996
Data Source: STRINGDB
PXN
Novelty: 0.00082031
Score: 0.996
Data Source: Reactome,STRINGDB
CBL
Family: Enzyme
Novelty: 0.00114929
Score: 0.995
Data Source: Reactome,STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
Score: 0.994
Data Source: Reactome,STRINGDB
ELMO1
Novelty: 0.01598587
Score: 0.985
Data Source: Reactome,STRINGDB
ELMO2
Novelty: 0.04258272
Score: 0.983
Data Source: Reactome,STRINGDB
MAPK8
Family: Kinase
Novelty: 0.00055723
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score 404.84
PubMed score by year
PubTator Score 244.38
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait