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Tbio
CRK
Adapter molecule crk

Protein Summary
Description
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300574
  • ENSP00000300574
  • ENSG00000167193
  • ENST00000398970
  • ENSP00000381942

Symbol
  • p38
  • CRKII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
disease perturbation
0.95
transcription factor perturbation
0.94
kinase perturbation
0.93
pathway
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.84   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 571   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.84   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
82.7
intraocular pressure measurement
1
1
0
7.4
64
lymphocyte percentage of leukocytes
2
2
2
29.9
reticulocyte count
2
1
2
24.6
self reported educational attainment
1
1
1
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
82.7
intraocular pressure measurement
0
7.4
64
lymphocyte percentage of leukocytes
2
29.9
reticulocyte count
2
24.6
self reported educational attainment
1
17
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88508
12928
Rat
RGD:2405
54245
Dog
CRK proto-oncogene, adaptor protein
VGNC:54290
100684309
Horse
CRK proto-oncogene, adaptor protein
VGNC:51791
100072356
Cow
CRK proto-oncogene, adaptor protein
VGNC:27716
512841
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
CRK proto-oncogene, adaptor protein
Horse
CRK proto-oncogene, adaptor protein
Cow
CRK proto-oncogene, adaptor protein
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P46108-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (103)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signal transduction
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Cytokine Signaling in Immune system
Downstream signal transduction
Fcgamma receptor (FCGR) dependent phagocytosis
Hemostasis
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (360)
1 – 10 of 360
RAPGEF1
Tbio
Novelty: 0.00365765
Score: 0.998
Data Source: Reactome,STRINGDB
DOCK1
Tbio
Novelty: 0.00867391
Score: 0.997
Data Source: Reactome,STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.996
Data Source: Reactome,STRINGDB
ABL1
Tclin
Family: Kinase
Novelty: 0.00023803
Score: 0.996
Data Source: STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.996
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.995
Data Source: Reactome,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.994
Data Source: Reactome,STRINGDB
ELMO1
Tbio
Novelty: 0.01598587
Score: 0.985
Data Source: Reactome,STRINGDB
ELMO2
Tbio
Novelty: 0.04258272
Score: 0.983
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  404.84

PubMed score by year
PubTator Score  244.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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