Protein Summary
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
- ENST00000300574
- ENSP00000300574
- ENSG00000167193
- ENST00000398970
- ENSP00000381942
- p38
- CRKII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 0.99 | ||
disease perturbation | 0.95 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
pathway | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 412.2 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 571 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 412.2 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 571 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (360)
Nearest Tclin Targets (19)
Upstream (18)
Downstream (1)
1 – 5 of 18
Pathways (103)
Reactome (32)
KEGG (18)
PathwayCommons (35)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ARMS-mediated activation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Downstream signal transduction | ||||
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ARMS-mediated activation | ||||
Cytokine Signaling in Immune system | ||||
Downstream signal transduction | ||||
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (47)
Functions (11)
Components (8)
Processes (28)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 4 | 4 | 94.2 | |||||
lymphocyte percentage of leukocytes | 2 | 3 | 3 | 89.6 | |||||
neutrophil count | 3 | 2 | 3 | 80.4 | |||||
myeloid white cell count | 2 | 2 | 2 | 72.4 | |||||
C-reactive protein measurement | 2 | 2 | 2 | 68.4 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 94.2 | |||||
lymphocyte percentage of leukocytes | 3 | 89.6 | |||||
neutrophil count | 3 | 80.4 | |||||
myeloid white cell count | 2 | 72.4 | |||||
C-reactive protein measurement | 2 | 68.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:88508 | 12928 | ||||||
Rat | RGD:2405 | 54245 | ||||||
Dog | CRK proto-oncogene, adaptor protein | VGNC:54290 | 100684309 | |||||
Horse | CRK proto-oncogene, adaptor protein | VGNC:51791 | 100072356 | |||||
Cow | CRK proto-oncogene, adaptor protein | VGNC:27716 | 512841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | CRK proto-oncogene, adaptor protein | |||||
Horse | CRK proto-oncogene, adaptor protein | |||||
Cow | CRK proto-oncogene, adaptor protein | |||||
Publication Statistics
PubMed Score 412.20
PubMed score by year
PubTator Score 244.38
PubTator score by year
Related Publications
Text Mined References (199)
GeneRif Annotations (74)
Items per page:
0 of 0
PMID | Year | Title |
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