Tclin HTR3A 5-hydroxytryptamine receptor 3A

Protein Summary

Description

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P46098
• B4DSY6
• G5E986
• O60854
• Q7KZM7
• Q99918
• Q9BSZ9
• 5-HT3-A

Gene Name

• HTR3A

Ensembl ID

• ENST00000299961
• ENSP00000299961
• ENSG00000166736
• ENST00000355556
• ENSP00000347754
• ENST00000375498
• ENSP00000364648
• ENST00000504030
• ENSP00000424189
• ENST00000506841
• ENSP00000424776

Symbol

• 5HT3R
• HTR3
• HTR3
• 5HT3R
• 5-HT-3
• 5-HT3A
• 5-HT3R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
drug	0.92
protein domain	0.92
disease	0.87
phenotype	0.85

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / 5-hydroxytryptamine Receptor 3a

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / 5-hydroxytryptamine Receptor 3a

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / 5-hydroxytryptamine Receptor 3a

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / 5-hydroxytryptamine Receptor 3a

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / 5-hydroxytryptamine Receptor Subfamily / 5-ht3 Receptor Sub-subfamily / 5-hydroxytryptamine Receptor 3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 585.46   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 585.46   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 734

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20