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Tchem
GPR6
G-protein coupled receptor 6

Protein Summary
Description
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275169
  • ENSP00000275169
  • ENSG00000146360
  • ENST00000414000
  • ENSP00000406986
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.61
protein domain
0.58
gene perturbation
0.57
transcription factor
0.55
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 321
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (60)
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.860350246
p_ni:  0.139649754
Score:  0.156
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.763315137
p_ni:  0.236587598
p_wrong:  0.000097265
Score:  0.195
Data Source:  BioPlex,STRINGDB
GRIK5
Tclin
Family:  IC
Novelty:  0.00346213
Score:  0.829
Data Source:  STRINGDB
NR2E1
Tbio
Family:  NR
Novelty:  0.0184868
Score:  0.767
Data Source:  STRINGDB
GPR88
Tchem
Family:  GPCR
Novelty:  0.02963528
Score:  0.721
Data Source:  STRINGDB
GRIK2
Tclin
Family:  IC
Novelty:  0.00293615
Score:  0.66
Data Source:  STRINGDB
GPR63
Tchem
Family:  GPCR
Novelty:  0.28759528
Score:  0.613
Data Source:  STRINGDB
NPBWR1
Tchem
Family:  GPCR
Novelty:  0.03520069
Score:  0.597
Data Source:  STRINGDB
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
Score:  0.586
Data Source:  STRINGDB
MBTPS1
Tchem
Family:  Enzyme
Novelty:  0.00845881
Score:  0.585
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
3.9
Find similar targets by:
IDG Resources
Genetic Construct
GPR6-Tango
image for GPR6-Tango
Details:
  • Vector:  addgene66365
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR6-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 6
VGNC:11087
104001079
Macaque
G protein-coupled receptor 6
697979
Mouse
MGI:2155249
140741
Rat
RGD:70939
83683
Dog
G protein-coupled receptor 6
VGNC:41439
481959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 6
Macaque
G protein-coupled receptor 6
Mouse
Rat
Dog
G protein-coupled receptor 6
Publication Statistics
PubMed Score 20.09
PubMed score by year
PubTator Score 8.21
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title