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Tchem
GPR6
G-protein coupled receptor 6

Protein Summary
Description
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275169
  • ENSP00000275169
  • ENSG00000146360
  • ENST00000414000
  • ENSP00000406986
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.61
protein domain
0.58
gene perturbation
0.57
transcription factor
0.55
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 344
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0