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Tbio
XCR1
Chemokine XC receptor 1

Protein Summary
Description
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309285
  • ENSP00000310405
  • ENSG00000173578

Symbol
  • CCXCR1
  • GPR5
  • GPR5
  • CCXCR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
protein domain
0.58
biological process
0.51
kinase perturbation
0.48
ligand (protein)
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
2
0
1.1
97
C-X-C motif chemokine 16 measurement
1
1
1
18.2
eosinophil percentage of granulocytes
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
97
C-X-C motif chemokine 16 measurement
1
18.2
eosinophil percentage of granulocytes
1
0.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-C motif chemokine receptor 1
VGNC:12240
460321
Macaque
X-C motif chemokine receptor 1
713622
Mouse
MGI:1346338
23832
Rat
RGD:1311480
301086
Dog
X-C motif chemokine receptor 1
VGNC:48447
484792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-C motif chemokine receptor 1
Macaque
X-C motif chemokine receptor 1
Mouse
Rat
Dog
X-C motif chemokine receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46094-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (244)
1 – 10 of 244
XCL2
Tbio
Novelty: 0.05252386
Score: 0.996
Data Source: Reactome,STRINGDB
XCL1
Tbio
Novelty: 0.00429108
Score: 0.996
Data Source: Reactome,STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.924
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.923
Data Source: STRINGDB
GPR65
Tbio
Family: GPCR
Novelty: 0.02341854
Score: 0.921
Data Source: STRINGDB
GNG5
Tbio
Novelty: 0.1525101
Score: 0.919
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.918
Data Source: STRINGDB
PLCB2
Tbio
Family: Enzyme
Novelty: 0.00571285
Score: 0.918
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.918
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.61

PubMed score by year
PubTator Score  39.26

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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