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Tchem
CCR10
C-C chemokine receptor type 10

Protein Summary
Description
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are invol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332438
  • ENSP00000332504
  • ENSG00000184451

Symbol
  • GPR2
  • GPR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.84
transcription factor binding site profile
0.75
gene perturbation
0.69
cell line
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.91   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.91   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
5
5
80.9
BMI-adjusted waist-hip ratio
2
5
5
78.5
3
2
1
1.1
60.2
waist circumference
1
2
2
43.8
triglyceride measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
80.9
BMI-adjusted waist-hip ratio
5
78.5
1
1.1
60.2
waist circumference
2
43.8
triglyceride measurement
1
38.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 10
VGNC:12046
741917
Macaque
C-C motif chemokine receptor 10 [Source:HGNC Symbol;Acc:HGNC:4474]
Mouse
MGI:1096320
12777
Rat
RGD:1310716
363682
Dog
C-C motif chemokine receptor 10
VGNC:38911
607528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 10
Macaque
C-C motif chemokine receptor 10 [Source:HGNC Symbol;Acc:HGNC:4474]
Mouse
Rat
Dog
C-C motif chemokine receptor 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46092-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (269)
1 – 10 of 269
CCL27
Tbio
Novelty:  0.00163457
Score:  0.99
Data Source:  Reactome,STRINGDB
CCL28
Tbio
Novelty:  0.00513161
Score:  0.975
Data Source:  Reactome,STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.968
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.964
Data Source:  STRINGDB
CCL25
Tbio
Novelty:  0.00824289
Score:  0.963
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.96
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.957
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.945
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.942
Data Source:  STRINGDB
CCL4L1
Tbio
Novelty:  0.00164787
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  63.91

PubMed score by year
PubTator Score  61.8

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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