Tchem GPR1 G-protein coupled receptor 1

Protein Summary

Description

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.

Uniprot Accession IDs

• P46091
• A5JUU6
• A8K4L1
• Q53TR9
• Q6NVX4

Gene Name

• GPR1

Ensembl ID

• ENST00000407325
• ENSP00000384345
• ENSG00000183671
• ENST00000437420
• ENSP00000397535
• ENST00000612892
• ENSP00000480405
• ENST00000621141
• ENSP00000483003
• ENST00000636848
• ENSP00000490642
• ENSG00000283448
• ENST00000637075
• ENSP00000490813
• ENST00000638097
• ENSP00000490453
• ENST00000638116
• ENSP00000489673

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.93
PubMedID	0.68
tissue sample	0.64
small molecule perturbation	0.6
gene perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / G-protein Coupled Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.53   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.53   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0