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Tchem
GPR1
G-protein coupled receptor 1

Protein Summary
Description
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407325
  • ENSP00000384345
  • ENSG00000183671
  • ENST00000437420
  • ENSP00000397535
  • ENST00000612892
  • ENSP00000480405
  • ENST00000621141
  • ENSP00000483003
  • ENST00000636848
  • ENSP00000490642
  • ENSG00000283448
  • ENST00000637075
  • ENSP00000490813
  • ENST00000638097
  • ENSP00000490453
  • ENST00000638116
  • ENSP00000489673
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
PubMedID
0.68
tissue sample
0.64
small molecule perturbation
0.6
gene perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (32)
RARRES2
Tbio
Novelty:  0.0029178
Score:  0.871
Data Source:  STRINGDB
GPHA2
Tbio
Novelty:  0.01057969
Score:  0.796
Data Source:  STRINGDB
GPR22
Tbio
Family:  GPCR
Novelty:  0.1822753
Score:  0.756
Data Source:  STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
Score:  0.637
Data Source:  STRINGDB
GPR3
Tchem
Family:  GPCR
Novelty:  0.02331106
Score:  0.635
Data Source:  STRINGDB
ZDBF2
Tdark
Novelty:  0.19205154
Score:  0.627
Data Source:  STRINGDB
TPK1
Tbio
Family:  Kinase
Novelty:  0.00899463
Score:  0.599
Data Source:  STRINGDB
ADGRG6
Tbio
Family:  GPCR
Novelty:  0.01186813
Score:  0.563
Data Source:  STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
Score:  0.556
Data Source:  STRINGDB
GPX2
Tbio
Family:  Enzyme
Novelty:  0.00479104
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
83.2
comparative body size at age 10, self-reported
1
1
1
83.2
self reported educational attainment
1
1
1
45.7
self reported educational attainment
1
1
1
45.7
reticulocyte count
2
2
2
39.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
83.2
comparative body size at age 10, self-reported
1
83.2
self reported educational attainment
1
45.7
self reported educational attainment
1
45.7
reticulocyte count
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 1
VGNC:1948
470621
Macaque
G protein-coupled receptor 1
707120
Mouse
MGI:2385324
241070
Rat
RGD:2728
25457
Dog
G protein-coupled receptor 1
VGNC:41390
478882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 1
Macaque
G protein-coupled receptor 1
Mouse
Rat
Dog
G protein-coupled receptor 1
Publication Statistics
PubMed Score 72.65
PubMed score by year
PubTator Score 24.21
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title