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Tbio
GPR1
G-protein coupled receptor 1

Protein Summary
Description
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407325
  • ENSP00000384345
  • ENSG00000183671
  • ENST00000437420
  • ENSP00000397535
  • ENST00000612892
  • ENSP00000480405
  • ENST00000621141
  • ENSP00000483003
  • ENST00000636848
  • ENSP00000490642
  • ENSG00000283448
  • ENST00000637075
  • ENSP00000490813
  • ENST00000638097
  • ENSP00000490453
  • ENST00000638116
  • ENSP00000489673
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
PubMedID
0.68
tissue sample
0.64
small molecule perturbation
0.6
gene perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.45   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.45   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
69.9
comparative body size at age 10, self-reported
1
1
1
69.9
body mass index
1
1
1
26.6
body mass index
1
1
1
26.6
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
69.9
comparative body size at age 10, self-reported
1
69.9
body mass index
1
26.6
body mass index
1
26.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 1
VGNC:1948
470621
Macaque
G protein-coupled receptor 1
707120
Mouse
MGI:2385324
241070
Rat
RGD:2728
25457
Dog
G protein-coupled receptor 1
VGNC:41390
478882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 1
Macaque
G protein-coupled receptor 1
Mouse
Rat
Dog
G protein-coupled receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46091-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (32)
1 – 10 of 32
RARRES2
Tbio
Novelty: 0.0029178
Score: 0.871
Data Source: STRINGDB
GPHA2
Tbio
Novelty: 0.01057969
Score: 0.796
Data Source: STRINGDB
GPR22
Tbio
Family: GPCR
Novelty: 0.1822753
Score: 0.756
Data Source: STRINGDB
CLEC2D
Tbio
Novelty: 0.02501194
Score: 0.637
Data Source: STRINGDB
GPR3
Tchem
Family: GPCR
Novelty: 0.02331106
Score: 0.635
Data Source: STRINGDB
ZDBF2
Tdark
Novelty: 0.19205154
Score: 0.627
Data Source: STRINGDB
TPK1
Tbio
Family: Kinase
Novelty: 0.00899463
Score: 0.599
Data Source: STRINGDB
ADGRG6
Tbio
Family: GPCR
Novelty: 0.01186813
Score: 0.563
Data Source: STRINGDB
RIC8A
Tbio
Novelty: 0.01846696
Score: 0.556
Data Source: STRINGDB
GPX2
Tbio
Family: Enzyme
Novelty: 0.00479104
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.45

PubMed score by year
PubTator Score  24.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer