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Tbio
NOP2
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

Protein Summary
Description
Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322166
  • ENSP00000313272
  • ENSG00000111641
  • ENST00000382421
  • ENSP00000371858
  • ENST00000399466
  • ENSP00000382392
  • ENST00000537442
  • ENSP00000444437
  • ENST00000541778
  • ENSP00000443150
  • ENST00000545200
  • ENSP00000439422
  • ENST00000617555
  • ENSP00000484384
  • ENST00000620535
  • ENSP00000479320

Symbol
  • NOL1
  • NSUN1
  • NOL1
  • p120
  • NSUN1
  • NOP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
hub protein
0.92
protein domain
0.92
histone modification site profile
0.9
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (333)
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.988540729
p_ni:  0.011459271
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.981251001
p_ni:  0.018748999
Score:  0.509
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.974415637
p_ni:  0.025584363
Score:  0.921
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.967200459
p_ni:  0.032799541
Score:  0.346
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.965710963
p_ni:  0.034289037
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.960045024
p_ni:  0.039954976
Score:  0.988
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.94707126
p_ni:  0.05292874
Data Source:  BioPlex
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.94284133
p_ni:  0.05715867
Score:  0.972
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.941850234
p_ni:  0.058149766
Data Source:  BioPlex
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.928441165
p_ni:  0.071558835
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (86)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Reactome
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
RNA Polymerase II Transcription
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
67.1
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
heel bone mineral density
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
67.1
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
heel bone mineral density
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP2 nucleolar protein
VGNC:8496
451784
Macaque
NOP2 nucleolar protein
713097
Mouse
MGI:107891
110109
Rat
RGD:1304616
314969
Dog
NOP2 nucleolar protein
VGNC:43889
611645
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP2 nucleolar protein
Macaque
NOP2 nucleolar protein
Mouse
Rat
Dog
NOP2 nucleolar protein
Publication Statistics
PubMed Score 62.10
PubMed score by year
PubTator Score 47.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title