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Tbio
NOP2
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

Protein Summary
Description
Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322166
  • ENSP00000313272
  • ENSG00000111641
  • ENST00000382421
  • ENSP00000371858
  • ENST00000399466
  • ENSP00000382392
  • ENST00000537442
  • ENSP00000444437
  • ENST00000541778
  • ENSP00000443150
  • ENST00000545200
  • ENSP00000439422
  • ENST00000617555
  • ENSP00000484384
  • ENST00000620535
  • ENSP00000479320

Symbol
  • NOL1
  • NSUN1
  • NOL1
  • p120
  • NSUN1
  • NOP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
hub protein
0.92
protein domain
0.92
histone modification site profile
0.9
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (86)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Reactome
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
RNA Polymerase II Transcription
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (333)
1 – 10 of 333
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.988540729
p_ni: 0.011459271
Data Source: BioPlex
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.981251001
p_ni: 0.018748999
Score: 0.509
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.974415637
p_ni: 0.025584363
Score: 0.921
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.967200459
p_ni: 0.032799541
Score: 0.346
Data Source: BioPlex,STRINGDB
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.965710963
p_ni: 0.034289037
Data Source: BioPlex
PUM3
Tbio
Novelty: 0.02344206
p_int: 0.960045024
p_ni: 0.039954976
Score: 0.988
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.94707126
p_ni: 0.05292874
Data Source: BioPlex
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.94284133
p_ni: 0.05715867
Score: 0.972
Data Source: BioPlex,STRINGDB
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.941850234
p_ni: 0.058149766
Data Source: BioPlex
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.928441165
p_ni: 0.071558835
Data Source: BioPlex
Publication Statistics
PubMed Score  59.59

PubMed score by year
PubTator Score  47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer