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Tchem
SLC15A1
Solute carrier family 15 member 1

Protein Summary
Description
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products. This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376503
  • ENSP00000365686
  • ENSG00000088386

Symbol
  • PEPT1
  • PEPT1
  • HPECT1
  • HPEPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
co-expressed gene
0.99
cell type or tissue
0.79
molecular function
0.7
biological term
0.69


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.4   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.4   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
1
1
0
1.3
58.1
blood urea nitrogen measurement
2
1
2
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
0
1.3
58.1
blood urea nitrogen measurement
2
6.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 1
VGNC:7834
467307
Macaque
solute carrier family 15 member 1
574257
Mouse
MGI:1861376
56643
Rat
RGD:621736
117261
Dog
solute carrier family 15 member 1
VGNC:46232
403561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 1
Macaque
solute carrier family 15 member 1
Mouse
Rat
Dog
solute carrier family 15 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46059-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Proton/oligopeptide cotransporters (R-HSA-427975)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Proton/oligopeptide cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Proton/oligopeptide cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (171)
1 – 10 of 171
TAMM41
Tbio
Family: Enzyme
Novelty: 0.06004824
p_int: 0.99997146
p_ni: 0.00002854
Data Source: BioPlex
C4A
Tbio
Novelty: 0.00062793
p_int: 0.999390947
p_ni: 0.000609053
Data Source: BioPlex
TMUB2
Tdark
Novelty: 1.76302035
p_int: 0.99924404
p_ni: 0.000644739
p_wrong: 0.000111221
Data Source: BioPlex
HACD1
Tbio
Family: Enzyme
Novelty: 0.02323512
p_int: 0.995579607
p_ni: 0.001530202
p_wrong: 0.00289019
Data Source: BioPlex
RTL8C
Tbio
Novelty: 0.20316911
p_int: 0.993353375
p_ni: 0.006641469
p_wrong: 0.000005156
Data Source: BioPlex
SLC25A24
Tbio
Family: Transporter
Novelty: 0.06151955
p_int: 0.990834425
p_ni: 0.009165383
p_wrong: 1.92e-7
Data Source: BioPlex
PDS5B
Tbio
Novelty: 0.00295057
p_int: 0.989670817
p_ni: 0.010329183
p_wrong: 1e-9
Data Source: BioPlex
SLC25A28
Tbio
Family: Transporter
Novelty: 0.05050869
p_int: 0.989298036
p_ni: 0.000001783
p_wrong: 0.01070018
Score: 0.213
Data Source: BioPlex,STRINGDB
SFXN3
Tbio
Novelty: 0.18698456
p_int: 0.987831191
p_ni: 0.009308617
p_wrong: 0.002860192
Data Source: BioPlex
CDYL
Tchem
Family: Epigenetic
Novelty: 0.03367841
p_int: 0.986230096
p_ni: 0.013763466
p_wrong: 0.000006437
Score: 0.15
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  717.40

PubMed score by year
PubTator Score  390.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer