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Tbio
PHKA1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

Protein Summary
Description
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339490
  • ENSP00000342469
  • ENSG00000067177
  • ENST00000373542
  • ENSP00000362643
  • ENST00000541944
  • ENSP00000441251

Symbol
  • PHKA
  • PHKA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.91
kinase
0.9
microRNA
0.84
histone modification site profile
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphorylase kinase regulatory subunit alpha 1
699764
Mouse
MGI:97576
18679
Rat
RGD:621522
64561
Dog
phosphorylase kinase regulatory subunit alpha 1
VGNC:44496
491956
Horse
phosphorylase kinase regulatory subunit alpha 1
VGNC:21390
100051524
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphorylase kinase regulatory subunit alpha 1
Mouse
Rat
Dog
phosphorylase kinase regulatory subunit alpha 1
Horse
phosphorylase kinase regulatory subunit alpha 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46020-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999997077
p_ni:  0.000002923
p_wrong:  1e-9
Score:  0.773
Data Source:  BioPlex,STRINGDB
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.999989525
p_ni:  0.000010475
Score:  0.307
Data Source:  BioPlex,STRINGDB
C1QTNF9
Tbio
Novelty:  0.03485116
p_int:  0.999933538
p_ni:  0.000066462
Score:  0.201
Data Source:  BioPlex,STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
p_int:  0.978263329
p_ni:  0.021732473
p_wrong:  0.000004198
Score:  0.197
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.92886739
p_ni:  0.071106178
p_wrong:  0.000026432
Data Source:  BioPlex
PHKG1
Tchem
Family:  Kinase
Novelty:  0.08576384
Score:  0.981
Data Source:  Reactome,STRINGDB
PYGM
Tchem
Family:  Enzyme
Novelty:  0.00507768
Score:  0.959
Data Source:  Reactome,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.95
Data Source:  Reactome,STRINGDB
PYGB
Tchem
Family:  Enzyme
Novelty:  0.00224148
Score:  0.936
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  33.59

PubMed score by year
PubTator Score  11.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer