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Tchem
MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353533
  • ENSP00000262445
  • ENSG00000065559
  • ENST00000415385
  • ENSP00000410402

Symbol
  • JNKK1
  • MEK4
  • MKK4
  • PRKMK4
  • SEK1
  • SERK1
  • SKK1
  • JNKK
  • MEK4
  • MKK4
  • SEK1
  • SKK1
  • JNKK1
  • SERK1
  • MAPKK4
  • PRKMK4
  • SAPKK1
  • SAPKK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
biological process
0.98
molecular function
0.98
pathway
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.12   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 1275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.12   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 1275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (178)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (157)
1 – 10 of 157
MAPK8
Tchem
Family: Kinase
Novelty: 0.00013952
Score: 0.991
Data Source: Reactome,STRINGDB
MAPK10
Tchem
Family: Kinase
Novelty: 0.0047523
Score: 0.99
Data Source: Reactome,STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00697684
Score: 0.989
Data Source: Reactome,STRINGDB
MAPK9
Tchem
Family: Kinase
Novelty: 0.00197999
Score: 0.988
Data Source: Reactome,STRINGDB
MAP3K1
Tchem
Family: Kinase
Novelty: 0.00673188
Score: 0.988
Data Source: Reactome,STRINGDB
CD40
Tchem
Novelty: 0.0003399
Score: 0.98
Data Source: STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00192027
Score: 0.963
Data Source: Reactome,STRINGDB
MAP3K11
Tchem
Family: Kinase
Novelty: 0.01297827
Score: 0.962
Data Source: STRINGDB
MAP3K2
Tchem
Family: Kinase
Novelty: 0.02884185
Score: 0.962
Data Source: STRINGDB
MAP3K3
Tchem
Family: Kinase
Novelty: 0.01604934
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.12

PubMed score by year
PubTator Score  304.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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