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Tchem
MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353533
  • ENSP00000262445
  • ENSG00000065559
  • ENST00000415385
  • ENSP00000410402

Symbol
  • JNKK1
  • MEK4
  • MKK4
  • PRKMK4
  • SEK1
  • SERK1
  • SKK1
  • JNKK
  • MEK4
  • MKK4
  • SEK1
  • SKK1
  • JNKK1
  • SERK1
  • MAPKK4
  • PRKMK4
  • SAPKK1
  • SAPKK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
biological process
0.98
molecular function
0.98
pathway
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.91   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 1275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.91   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 1275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (157)
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.991
Data Source:  Reactome,STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.99
Data Source:  Reactome,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.989
Data Source:  Reactome,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
Score:  0.988
Data Source:  Reactome,STRINGDB
MAP3K1
Tchem
Family:  Kinase
Novelty:  0.0041131
Score:  0.988
Data Source:  Reactome,STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.98
Data Source:  STRINGDB
MAP3K5
Tchem
Family:  Kinase
Novelty:  0.00144614
Score:  0.963
Data Source:  Reactome,STRINGDB
MAP3K11
Tchem
Family:  Kinase
Novelty:  0.01112378
Score:  0.962
Data Source:  STRINGDB
MAP3K2
Tchem
Family:  Kinase
Novelty:  0.01201472
Score:  0.962
Data Source:  STRINGDB
MAP3K3
Tchem
Family:  Kinase
Novelty:  0.01607002
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets (10)
Explore Nearest Tclin Targets
1 – 3 of 3
PRKCD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (178)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carotid artery intima media thickness
4
3
4
89.7
Oral cleft
1
1
1
58.2
aortic measurement
3
2
3
39.7
educational attainment
1
2
2
37.4
Inguinal hernia
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carotid artery intima media thickness
4
89.7
Oral cleft
1
58.2
aortic measurement
3
39.7
educational attainment
2
37.4
Inguinal hernia
1
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 4
VGNC:9364
455065
Macaque
mitogen-activated protein kinase kinase 4
718155
Mouse
MGI:1346869
26398
Rat
RGD:1307040
287398
Dog
mitogen-activated protein kinase kinase 4
VGNC:42962
489508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 4
Macaque
mitogen-activated protein kinase kinase 4
Mouse
Rat
Dog
mitogen-activated protein kinase kinase 4
Publication Statistics
PubMed Score 414.91
PubMed score by year
PubTator Score 304.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title