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Tchem
MAPK9
Mitogen-activated protein kinase 9

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343111
  • ENSP00000345524
  • ENSG00000050748
  • ENST00000393360
  • ENSP00000377028
  • ENST00000425491
  • ENSP00000397422
  • ENST00000452135
  • ENSP00000394560
  • ENST00000455781
  • ENSP00000389338

Symbol
  • JNK2
  • PRKM9
  • SAPK1A
  • JNK2
  • SAPK
  • p54a
  • JNK2A
  • JNK2B
  • PRKM9
  • JNK-55
  • SAPK1a
  • JNK2BETA
  • p54aSAPK
  • JNK2ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
molecular function
1
kinase perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.11   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 790   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.11   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 790   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (208)
Activation of the AP-1 family of transcription factors (R-HSA-450341)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of the AP-1 family of transcription factors
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (320)
1 – 10 of 320
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
p_int: 0.999999865
p_ni: 5e-9
p_wrong: 1.3e-7
Score: 0.967
Data Source: BioPlex,STRINGDB
C6orf222
Tdark
Novelty: 37
p_int: 0.999972619
p_ni: 0.000027379
p_wrong: 3e-9
Data Source: BioPlex
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.99996341
p_ni: 0.00003659
Score: 0.22
Data Source: BioPlex,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.999951786
p_ni: 0.000048214
Data Source: BioPlex
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.999941428
p_ni: 0.000058572
Data Source: BioPlex
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
p_int: 0.999829924
p_ni: 0.000170076
Score: 0.983
Data Source: BioPlex,STRINGDB
LRRC56
Tdark
Novelty: 1.32360532
p_int: 0.998691467
p_ni: 0.001308523
p_wrong: 1e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
RHPN1
Tbio
Novelty: 0.05722992
p_int: 0.997061077
p_ni: 0.002938922
p_wrong: 1e-9
Data Source: BioPlex
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.996984793
p_ni: 0.003015207
Data Source: BioPlex
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.996801866
p_ni: 0.003198131
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  321.11

PubMed score by year
PubTator Score  561.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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