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Tchem
MAPK8
Mitogen-activated protein kinase 8

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360332
  • ENSP00000353483
  • ENSG00000107643
  • ENST00000374176
  • ENSP00000363291
  • ENST00000374179
  • ENSP00000363294
  • ENST00000374182
  • ENSP00000363297
  • ENST00000374189
  • ENSP00000363304
  • ENST00000395611
  • ENSP00000378974

Symbol
  • JNK1
  • PRKM8
  • SAPK1
  • SAPK1C
  • JNK
  • JNK1
  • PRKM8
  • SAPK1
  • JNK-46
  • JNK1A2
  • SAPK1c
  • JNK21B1/2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
interacting protein
1
pathway
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1603.32   (req: < 5)
Gene RIFs: 640   (req: <= 3)
Antibodies: 1542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1603.32   (req: >= 5)
Gene RIFs: 640   (req: > 3)
Antibodies: 1542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 301
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1