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Tchem
MAPK8
Mitogen-activated protein kinase 8

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360332
  • ENSP00000353483
  • ENSG00000107643
  • ENST00000374176
  • ENSP00000363291
  • ENST00000374179
  • ENSP00000363294
  • ENST00000374182
  • ENSP00000363297
  • ENST00000374189
  • ENSP00000363304
  • ENST00000395611
  • ENSP00000378974

Symbol
  • JNK1
  • PRKM8
  • SAPK1
  • SAPK1C
  • JNK
  • JNK1
  • PRKM8
  • SAPK1
  • JNK-46
  • JNK1A2
  • SAPK1c
  • JNK21B1/2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
interacting protein
1
pathway
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1518   (req: < 5)
Gene RIFs: 604   (req: <= 3)
Antibodies: 1542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1518   (req: >= 5)
Gene RIFs: 604   (req: > 3)
Antibodies: 1542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 277
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (885)
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.999999865
p_ni:  5e-9
p_wrong:  1.3e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
DUSP8
Tbio
Family:  Enzyme
Novelty:  0.0105002
p_int:  0.999999487
p_ni:  4.1e-8
p_wrong:  4.72e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
p_int:  0.99999692
p_ni:  0.000003075
p_wrong:  5e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
WDR62
Tbio
Novelty:  0.02611137
p_int:  0.99999563
p_ni:  0.00000437
Score:  0.84
Data Source:  BioPlex,STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
p_int:  0.999930947
p_ni:  0.000066838
p_wrong:  0.000002215
Score:  0.997
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.999666294
p_ni:  0.000333691
p_wrong:  1.6e-8
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999274072
p_ni:  0.000725102
p_wrong:  8.26e-7
Data Source:  BioPlex
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.991243365
p_ni:  0.008756635
Score:  0.205
Data Source:  BioPlex,STRINGDB
C6orf222
Tdark
Novelty:  37
p_int:  0.989156953
p_ni:  0.000246592
p_wrong:  0.010596455
Data Source:  BioPlex
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
1 – 5 of 5
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  30
more:  26 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  13
more:  9 more common pathways
RAF1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  27
more:  23 more common pathways
PGR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  1
Common Pathways:  1
Pathways (287)
Activation of BH3-only proteins (R-HSA-114452)

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1 – 5 of 53
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of BIM and translocation to mitochondria
Reactome
Activation of BMF and translocation to mitochondria
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Apoptosis
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Activation of the AP-1 family of transcription factors
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
1
1
24.5
sex hormone-binding globulin measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
24.5
sex hormone-binding globulin measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8
VGNC:14517
450445
Macaque
mitogen-activated protein kinase 8
711115
Rat
RGD:621506
116554
Dog
mitogen-activated protein kinase 8
VGNC:43001
477746
Horse
mitogen-activated protein kinase 8
VGNC:19962
100051798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8
Macaque
mitogen-activated protein kinase 8
Rat
Dog
mitogen-activated protein kinase 8
Horse
mitogen-activated protein kinase 8
Publication Statistics
PubMed Score 1518.00
PubMed score by year
PubTator Score 3897.64
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title