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Tchem
USP5
Ubiquitin carboxyl-terminal hydrolase 5

Protein Summary
Description
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229268
  • ENSP00000229268
  • ENSG00000111667
  • ENST00000389231
  • ENSP00000373883

Symbol
  • ISOT
  • ISOT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.98
transcription factor binding site profile
0.91
histone modification site profile
0.84
small molecule perturbation
0.82


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.3   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.3   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
vialinin A
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 5
VGNC:13492
451798
Macaque
ubiquitin specific peptidase 5
714032
Mouse
MGI:1347343
22225
Dog
ubiquitin specific peptidase 5
VGNC:48201
486718
Horse
ubiquitin specific peptidase 5
VGNC:24850
100060068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 5
Macaque
ubiquitin specific peptidase 5
Mouse
Dog
ubiquitin specific peptidase 5
Horse
ubiquitin specific peptidase 5
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P45974-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (167)
1 – 10 of 167
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.869889291
p_ni: 0.130110709
Data Source: BioPlex
UBC
Tbio
Novelty: 0.00204643
Score: 0.998
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.996
Data Source: Reactome,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.996
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.955
Data Source: STRINGDB
UCHL3
Tchem
Family: Enzyme
Novelty: 0.01206871
Score: 0.883
Data Source: STRINGDB
USP14
Tchem
Family: Enzyme
Novelty: 0.00947074
Score: 0.881
Data Source: STRINGDB
URM1
Tbio
Novelty: 0.02579093
Score: 0.864
Data Source: STRINGDB
YTHDF2
Tbio
Novelty: 0.01498605
Score: 0.863
Data Source: STRINGDB
UBE2H
Tbio
Novelty: 0.03259425
Score: 0.861
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.30

PubMed score by year
PubTator Score  36.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer