Tbio CBX5 Chromobox protein homolog 5

Protein Summary

Description

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P45973
• B2R8T9

Gene Name

• CBX5

Ensembl ID

• ENST00000209875
• ENSP00000209875
• ENSG00000094916
• ENST00000439541
• ENSP00000401009
• ENST00000550411
• ENSP00000449207

Symbol

• HP1A
• HP1
• HP1A
• HEL25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
drug perturbation	0.96
virus perturbation	0.94
transcription factor binding site profile	0.93
protein domain	0.85

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Methyl-lysine/arginine Binding Protein / Chromodomain / Chromobox Protein Homolog 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.88   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 838   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.88   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0