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Tbio
CBX5
Chromobox protein homolog 5

Protein Summary
Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209875
  • ENSP00000209875
  • ENSG00000094916
  • ENST00000439541
  • ENSP00000401009
  • ENST00000550411
  • ENSP00000449207

Symbol
  • HP1A
  • HP1
  • HP1A
  • HEL25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
drug perturbation
0.96
virus perturbation
0.94
transcription factor binding site profile
0.93
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.87   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 838   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.87   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.5
platelet count
5
5
6
8.7
98.4
red blood cell distribution width
4
2
6
95.6
mean corpuscular volume
1
2
2
94.4
reticulocyte measurement
2
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.5
platelet count
6
8.7
98.4
red blood cell distribution width
6
95.6
mean corpuscular volume
2
94.4
reticulocyte measurement
2
88
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromobox 5
VGNC:12873
467011
Macaque
chromobox 5
703477
Mouse
MGI:109372
12419
Rat
RGD:1306619
300266
Dog
chromobox 5
VGNC:38767
477593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromobox 5
Macaque
chromobox 5
Mouse
Rat
Dog
chromobox 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P45973-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
Metabolism of proteins
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (209)
1 – 10 of 209
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
p_int:  0.999965453
p_ni:  0.000034547
Score:  0.728
Data Source:  BioPlex,STRINGDB
SUV39H2
Tchem
Family:  Epigenetic
Novelty:  0.02232167
p_int:  0.999566117
p_ni:  0.000433883
Score:  0.558
Data Source:  BioPlex,STRINGDB
TCAP
Tbio
Novelty:  0.00623581
p_int:  0.999425984
p_ni:  0.000574016
Score:  0.189
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.998585476
p_ni:  0.001414524
Score:  0.624
Data Source:  BioPlex,STRINGDB
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.998288402
p_ni:  0.001711598
Score:  0.921
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.997718594
p_ni:  0.002281402
p_wrong:  4e-9
Score:  0.815
Data Source:  BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.996508748
p_ni:  0.003491252
Score:  0.84
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.990246918
p_ni:  0.00975307
p_wrong:  1.2e-8
Score:  0.615
Data Source:  BioPlex,STRINGDB
ZNF462
Tbio
Novelty:  0.13731082
p_int:  0.989673442
p_ni:  0.010326558
Score:  0.283
Data Source:  BioPlex,STRINGDB
CPLX4
Tdark
Novelty:  0.1755035
p_int:  0.985857554
p_ni:  0.014142446
Score:  0.199
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  149.87

PubMed score by year
PubTator Score  477.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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