Tchem VDAC2 Voltage-dependent anion-selective channel protein 2

Protein Summary

Description

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P45880
• Q5VWK1
• Q5VWK3
• Q6IB40
• Q7L3J5
• Q9BWK8
• Q9Y5I6
• VDAC-2

Gene Name

• VDAC2

Ensembl ID

• ENST00000313132
• ENSP00000361635
• ENSG00000165637
• ENST00000332211
• ENSP00000361686
• ENST00000543351
• ENSP00000443092

Symbol

• POR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	1
interacting protein	1
virus perturbation	0.96
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-dependent Anion-selective Channel Protein 2

Protein / Transporter / Ion Channel / Anion Channel / Voltage-dependent Anion-selective Channel Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0