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Tchem
VDAC2
Voltage-dependent anion-selective channel protein 2

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313132
  • ENSP00000361635
  • ENSG00000165637
  • ENST00000332211
  • ENSP00000361686
  • ENST00000543351
  • ENSP00000443092

Symbol
  • POR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
interacting protein
1
virus perturbation
0.96
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.79   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.79   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Pathways (20)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Mitochondrial calcium ion transport
Reactome
Post-translational protein modification
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Mitochondrial calcium ion transport
Post-translational protein modification
Transport of small molecules
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (185)
1 – 10 of 185
DENR
Tbio
Novelty: 0.00653432
p_int: 0.894247278
p_ni: 0.105752722
Score: 0.503
Data Source: BioPlex,STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.991
Data Source: STRINGDB
TOMM20
Tbio
Novelty: 0.00275824
Score: 0.973
Data Source: STRINGDB
TOMM70
Tbio
Novelty: 0.00943973
Score: 0.965
Data Source: STRINGDB
SLC25A5
Tbio
Family: Transporter
Novelty: 0.00749909
Score: 0.954
Data Source: STRINGDB
RHOT1
Tbio
Family: Enzyme
Novelty: 0.01411527
Score: 0.946
Data Source: STRINGDB
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.07666564
Score: 0.945
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00082324
Score: 0.944
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00082324
Score: 0.944
Data Source: STRINGDB
PPIF
Tchem
Family: Enzyme
Novelty: 0.00147732
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  167.79

PubMed score by year
PubTator Score  69.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer