Tbio PPIC Peptidyl-prolyl cis-trans isomerase C

Protein Summary

Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P45877
• A4LBB5
• PPIase C

Gene Name

• PPIC

Ensembl ID

• ENST00000306442
• ENSP00000303057
• ENSG00000168938

Symbol

• CYPC
• CYPC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
disease perturbation	0.87
transcription factor perturbation	0.8
virus perturbation	0.79
histone modification site profile	0.76

Protein Classes

DTO Classes

Peptidyl-prolyl Cis-trans Isomerase Cwc27 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.41   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.41   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0