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Tbio
ABCG1
ATP-binding cassette sub-family G member 1

Protein Summary
Description
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343687
  • ENSP00000339744
  • ENSG00000160179
  • ENST00000347800
  • ENSP00000291524
  • ENST00000361802
  • ENSP00000354995
  • ENST00000398449
  • ENSP00000381467
  • ENST00000398457
  • ENSP00000381475

Symbol
  • ABC8
  • WHT1
  • ABC8
  • WHITE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase perturbation
0.96
PubMedID
0.95
protein domain
0.92
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.66   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.66   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
13.5
birth weight
1
1
1
8.9
high density lipoprotein cholesterol measurement
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
13.5
birth weight
1
8.9
high density lipoprotein cholesterol measurement
1
4.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 1
VGNC:3739
458577
Macaque
ATP binding cassette subfamily G member 1
100423477
Mouse
MGI:107704
11307
Rat
RGD:620294
85264
Dog
ATP binding cassette subfamily G member 1
VGNC:37452
487777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 1
Macaque
ATP binding cassette subfamily G member 1
Mouse
Rat
Dog
ATP binding cassette subfamily G member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P45844-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (65)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
HDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
HDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (95)
1 – 10 of 95
SCARB1
Tchem
Novelty:  0.00087703
Score:  0.923
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.81
Data Source:  STRINGDB
NR1H3
Tchem
Family:  NR
Novelty:  0.00394862
Score:  0.794
Data Source:  STRINGDB
LCAT
Tchem
Family:  Enzyme
Novelty:  0.00307544
Score:  0.782
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.774
Data Source:  STRINGDB
CETP
Tchem
Novelty:  0.00051779
Score:  0.759
Data Source:  STRINGDB
NR1H2
Tchem
Family:  NR
Novelty:  0.01296966
Score:  0.747
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.735
Data Source:  STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.734
Data Source:  STRINGDB
PLTP
Tbio
Novelty:  0.00267612
Score:  0.721
Data Source:  STRINGDB
Publication Statistics
PubMed Score  453.66

PubMed score by year
PubTator Score  244.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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