Tbio ABCG1 ATP-binding cassette sub-family G member 1

Protein Summary

Description

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P45844
• Q86SU8
• Q96L76
• Q9BXK6
• Q9BXK7
• Q9BXK8
• Q9BXK9
• Q9BXL0
• Q9BXL1
• Q9BXL2
• Q9BXL3
• Q9BXL4

Gene Name

• ABCG1

Ensembl ID

• ENST00000343687
• ENSP00000339744
• ENSG00000160179
• ENST00000347800
• ENSP00000291524
• ENST00000361802
• ENSP00000354995
• ENST00000398449
• ENSP00000381467
• ENST00000398457
• ENSP00000381475

Symbol

• ABC8
• WHT1
• ABC8
• WHITE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
kinase perturbation	0.96
PubMedID	0.95
protein domain	0.92
biological process	0.9

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family G Member 1

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcg Subfamily / Atp-binding Cassette Sub-family G Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.59   (req: < 5)

Gene RIFs: 148   (req: <= 3)

Antibodies: 349   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.59   (req: >= 5)

Gene RIFs: 148   (req: > 3)

Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0