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Tbio
ASPA
Aspartoacylase

Protein Summary
Description
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263080
  • ENSP00000263080
  • ENSG00000108381
  • ENST00000456349
  • ENSP00000409976

Symbol
  • ACY2
  • ASP
  • ASP
  • ACY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.72
virus perturbation
0.64
disease
0.62
tissue sample
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartoacylase
VGNC:9124
454430
Mouse
MGI:87914
11484
Rat
RGD:621693
79251
Dog
aspartoacylase
VGNC:38184
611064
Horse
aspartoacylase
VGNC:15587
100060454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartoacylase
Mouse
Rat
Dog
aspartoacylase
Horse
aspartoacylase
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P45381-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
RUFY1
Tbio
Novelty: 0.16796947
p_int: 0.906568148
p_ni: 0.093431851
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
WASL
Tbio
Novelty: 0.0029314
p_int: 0.899805108
p_ni: 0.000235529
p_wrong: 0.099959364
Score: 0.325
Data Source: BioPlex,STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
p_int: 0.858555778
p_ni: 0.141443788
p_wrong: 4.34e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
NAT8L
Tbio
Family: Enzyme
Novelty: 0.01761988
Score: 0.935
Data Source: STRINGDB
FOLH1
Tchem
Family: Enzyme
Novelty: 0.0002861
Score: 0.927
Data Source: STRINGDB
RIMKLB
Tbio
Family: Enzyme
Novelty: 0.17814588
Score: 0.926
Data Source: STRINGDB
RIMKLA
Tdark
Family: Enzyme
Novelty: 0.30213465
Score: 0.925
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.911
Data Source: STRINGDB
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
Score: 0.911
Data Source: STRINGDB
ASNS
Tchem
Family: Enzyme
Novelty: 0.00337445
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.85

PubMed score by year
PubTator Score  120.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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