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Tbio
TNNT2
Troponin T, cardiac muscle

Protein Summary
Description
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236918
  • ENSP00000236918
  • ENSG00000118194
  • ENST00000360372
  • ENSP00000353535
  • ENST00000367318
  • ENSP00000356287
  • ENST00000367320
  • ENSP00000356289
  • ENST00000367322
  • ENSP00000356291
  • ENST00000509001
  • ENSP00000422031

Symbol
  • CMH2
  • RCM3
  • TnTC
  • cTnT
  • CMD1D
  • CMPD2
  • LVNC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
transcription factor perturbation
0.84
biological term
0.75
disease
0.63
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2345.28   (req: < 5)
Gene RIFs: 300   (req: <= 3)
Antibodies: 1078   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2345.28   (req: >= 5)
Gene RIFs: 300   (req: > 3)
Antibodies: 1078   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
1
1
1
30.4
electrocardiography
1
1
3
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
1
30.4
electrocardiography
3
17
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
troponin T2, cardiac type
VGNC:10924
457618
Macaque
ladinin 1 [Source:HGNC Symbol;Acc:HGNC:6472]
Mouse
MGI:104597
21956
Rat
RGD:3882
24837
Dog
troponin T2, cardiac type
VGNC:47691
403532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
troponin T2, cardiac type
Macaque
ladinin 1 [Source:HGNC Symbol;Acc:HGNC:6472]
Mouse
Rat
Dog
troponin T2, cardiac type
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P45379-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (167)
1 – 10 of 167
TNNI3
Tbio
Novelty: 0.00020053
Score: 0.998
Data Source: Reactome,STRINGDB
TNNI1
Tbio
Novelty: 0.01639536
Score: 0.995
Data Source: Reactome,STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.993
Data Source: STRINGDB
MYBPC3
Tbio
Novelty: 0.00297478
Score: 0.992
Data Source: STRINGDB
MYH6
Tbio
Novelty: 0.00058671
Score: 0.991
Data Source: STRINGDB
TNNC1
Tclin
Novelty: 0.03535727
Score: 0.987
Data Source: Reactome,STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.987
Data Source: STRINGDB
MYL2
Tbio
Novelty: 0.0018887
Score: 0.985
Data Source: STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.983
Data Source: STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  2345.28

PubMed score by year
PubTator Score  3056.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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