Tbio TNNT2 Troponin T, cardiac muscle

Protein Summary

Description

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P45379
• A2TDB9
• A8K3K6
• O60214
• Q99596
• Q99597
• Q9BUF6
• Q9UM96
• TnTc

Gene Name

• TNNT2

Ensembl ID

• ENST00000236918
• ENSP00000236918
• ENSG00000118194
• ENST00000360372
• ENSP00000353535
• ENST00000367318
• ENSP00000356287
• ENST00000367320
• ENSP00000356289
• ENST00000367322
• ENSP00000356291
• ENST00000509001
• ENSP00000422031

Symbol

• CMH2
• RCM3
• TnTC
• cTnT
• CMD1D
• CMPD2
• LVNC6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
transcription factor perturbation	0.84
biological term	0.75
disease	0.63
cellular component	0.62

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Troponin T, Cardiac Muscle

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Troponin T, Cardiac Muscle

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2885.63   (req: < 5)

Gene RIFs: 361   (req: <= 3)

Antibodies: 1078   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2885.63   (req: >= 5)

Gene RIFs: 361   (req: > 3)

Antibodies: 1078   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0