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Tbio
TSFM
Elongation factor Ts, mitochondrial

Protein Summary
Description
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323833
  • ENSP00000313877
  • ENSG00000123297
  • ENST00000454289
  • ENSP00000388330
  • ENST00000540550
  • ENSP00000440987
  • ENST00000543727
  • ENSP00000439342

Symbol
  • EFTS
  • EFTSMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.8
transcription factor perturbation
0.74
protein domain
0.73
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.97   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.97   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
94
urate measurement
1
1
1
71.9
high density lipoprotein cholesterol measurement
1
1
1
59.9
mathematical ability
2
2
2
57.7
apolipoprotein A 1 measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94
urate measurement
1
71.9
high density lipoprotein cholesterol measurement
1
59.9
mathematical ability
2
57.7
apolipoprotein A 1 measurement
1
52.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ts translation elongation factor, mitochondrial
VGNC:14418
452028
Macaque
Ts translation elongation factor, mitochondrial
715916
Mouse
MGI:1913649
66399
Rat
RGD:1593058
679068
Horse
Ts translation elongation factor, mitochondrial
VGNC:24576
100053864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ts translation elongation factor, mitochondrial
Macaque
Ts translation elongation factor, mitochondrial
Mouse
Rat
Horse
Ts translation elongation factor, mitochondrial
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43897-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Translation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (251)
1 – 10 of 251
ATXN7L2
Tdark
Novelty:  2.89202293
p_int:  0.999998503
p_wrong:  0.000001496
Score:  0.297
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.998228512
p_ni:  0.001771488
Data Source:  BioPlex
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.998158149
p_ni:  0.001841851
Score:  0.833
Data Source:  BioPlex,STRINGDB
CST2
Tbio
Novelty:  0.02114441
p_int:  0.997987227
p_ni:  0.001642242
p_wrong:  0.000370532
Score:  0.177
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.995375228
p_ni:  0.004624772
Score:  0.967
Data Source:  BioPlex,STRINGDB
CST4
Tbio
Novelty:  0.00773554
p_int:  0.982899541
p_ni:  0.017096495
p_wrong:  0.000003964
Data Source:  BioPlex
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.958815364
p_ni:  0.041183624
p_wrong:  0.000001012
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.939362031
p_ni:  0.060637969
Data Source:  BioPlex
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
p_int:  0.890514395
p_ni:  0.109485595
p_wrong:  1e-8
Score:  0.933
Data Source:  BioPlex,STRINGDB
IGHA1
Tbio
p_int:  0.804421045
p_ni:  0.195578955
Data Source:  BioPlex
Publication Statistics
PubMed Score  194.97

PubMed score by year
PubTator Score  39.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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