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Tbio
GATA4
Transcription factor GATA-4

Protein Summary
Description
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). This gene encodes a member of the GATA family of zinc-finger transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335135
  • ENSP00000334458
  • ENSG00000136574
  • ENST00000532059
  • ENSP00000435712
  • ENST00000643249
  • ENSP00000493647
  • ENSG00000285109
  • ENST00000647274
  • ENSP00000495511

Symbol
  • TOF
  • ASD2
  • VSD1
  • TACHD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
biological term
0.9
PubMedID
0.8
phenotype
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1110.71   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 668   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1110.71   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
6
7
97.1
C-reactive protein measurement
3
4
4
92.7
waist-hip ratio
2
17
17
88.8
neuroticism measurement
3
13
13
5.5
88.6
BMI-adjusted waist-hip ratio
1
13
13
86.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
97.1
C-reactive protein measurement
4
92.7
waist-hip ratio
17
88.8
neuroticism measurement
13
5.5
88.6
BMI-adjusted waist-hip ratio
13
86.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GATA binding protein 4
696775
Mouse
MGI:95664
14463
Rat
RGD:2665
54254
Dog
GATA binding protein 4
486079
Horse
GATA binding protein 4
VGNC:50696
100065126
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GATA binding protein 4
Mouse
Rat
Dog
GATA binding protein 4
Horse
GATA binding protein 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43694-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (55)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
Gene Ontology Terms (53)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (339)
1 – 10 of 339
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.998
Data Source:  Reactome,STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.993
Data Source:  STRINGDB
ZFPM2
Tbio
Family:  TF
Novelty:  0.01019523
Score:  0.992
Data Source:  STRINGDB
TBX5
Tbio
Family:  TF
Novelty:  0.00272208
Score:  0.985
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.984
Data Source:  STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.98
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.976
Data Source:  STRINGDB
HAND2
Tbio
Family:  TF
Novelty:  0.00478924
Score:  0.971
Data Source:  STRINGDB
NPPA
Tchem
Novelty:  0.00046693
Score:  0.967
Data Source:  STRINGDB
HEY2
Tbio
Family:  TF
Novelty:  0.00569776
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1110.71

PubMed score by year
PubTator Score  502.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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