You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CHRNA4
Neuronal acetylcholine receptor subunit alpha-4

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370263
  • ENSP00000359285
  • ENSG00000101204
  • ENST00000615287
  • ENSP00000483388

Symbol
  • NACRA4
  • EBN
  • BFNC
  • EBN1
  • NACHR
  • NACRA4
  • NACHRA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.96
molecular function
0.96
drug
0.89
protein domain
0.85
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.21   (req: < 5)
Gene RIFs: 147   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.21   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
3
5
98.5
smoking behaviour measurement
1
1
1
96.7
cigarettes per day measurement
2
1
2
96.5
smoking status measurement
2
1
2
91.9
smoking initiation
1
1
1
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
5
98.5
smoking behaviour measurement
1
96.7
cigarettes per day measurement
2
96.5
smoking status measurement
2
91.9
smoking initiation
1
83.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 4 subunit
VGNC:51755
469999
Macaque
cholinergic receptor nicotinic alpha 4 subunit [Source:HGNC Symbol;Acc:HGNC:1958]
Mouse
MGI:87888
11438
Rat
RGD:2346
25590
Dog
cholinergic receptor nicotinic alpha 4 subunit
VGNC:39239
485972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 4 subunit
Macaque
cholinergic receptor nicotinic alpha 4 subunit [Source:HGNC Symbol;Acc:HGNC:1958]
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 4 subunit
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly sodium permeable acetylcholine nicotinic receptors
Neuronal System
Protein-Protein Interactions (172)
1 – 10 of 172
CHRNB2
Tclin
Family: IC
Novelty: 0.01251655
Score: 0.966
Data Source: Reactome,STRINGDB
CHRNB4
Tclin
Family: IC
Novelty: 0.01151716
Score: 0.959
Data Source: STRINGDB
CHRNA5
Tbio
Family: IC
Novelty: 0.00425291
Score: 0.943
Data Source: STRINGDB
CHRNA7
Tchem
Family: IC
Novelty: 0.00590784
Score: 0.926
Data Source: STRINGDB
CHRNA9
Tchem
Family: IC
Novelty: 0.05009815
Score: 0.911
Data Source: STRINGDB
CHRNG
Tclin
Family: IC
Novelty: 0.03295438
Score: 0.91
Data Source: STRINGDB
CHRNB3
Tchem
Family: IC
Novelty: 0.031456
Score: 0.91
Data Source: Reactome,STRINGDB
CHRNE
Tclin
Family: IC
Novelty: 0.01908511
Score: 0.909
Data Source: STRINGDB
CHRND
Tclin
Family: IC
Novelty: 0.0441685
Score: 0.908
Data Source: STRINGDB
CHRNA2
Tchem
Family: IC
Novelty: 0.02542208
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  199.21

PubMed score by year
PubTator Score  1903.41

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: