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Tbio
KIR3DL2
Killer cell immunoglobulin-like receptor 3DL2

Protein Classes
Protein Summary
Description
Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270442
  • ENSP00000270442
  • ENSG00000240403
  • ENST00000326321
  • ENSP00000325525
  • ENST00000611608
  • ENSP00000479903
  • ENSG00000278809
  • ENST00000611628
  • ENSP00000481662
  • ENSG00000278474
  • ENST00000611859
  • ENSP00000480578
  • ENSG00000277181
  • ENST00000612138
  • ENSP00000482589
  • ENSG00000274722
  • ENST00000613610
  • ENSP00000482301
  • ENSG00000278442
  • ENST00000613612
  • ENSP00000482565
  • ENSG00000275566
  • ENST00000614753
  • ENSP00000479299
  • ENSG00000276357
  • ENST00000617354
  • ENSP00000482110
  • ENST00000617481
  • ENSP00000481306
  • ENSG00000275083
  • ENST00000617666
  • ENSP00000481209
  • ENSG00000278361
  • ENST00000617957
  • ENSP00000481579
  • ENST00000618273
  • ENSP00000481871
  • ENSG00000276739
  • ENST00000619683
  • ENSP00000478251
  • ENSG00000275626
  • ENST00000620817
  • ENSP00000479772
  • ENST00000621155
  • ENSP00000477519
  • ENSG00000275416
  • ENST00000622024
  • ENSP00000479425
  • ENSG00000276004
  • ENST00000622453
  • ENSP00000477516
  • ENST00000622579
  • ENSP00000482655
  • ENST00000638330
  • ENSP00000492261
  • ENSG00000284381
  • ENST00000638726
  • ENSP00000492117
  • ENSG00000283951
  • ENST00000638805
  • ENSP00000492880
  • ENSG00000283975
  • ENST00000638891
  • ENSP00000491303
  • ENSG00000284063
  • ENST00000638970
  • ENSP00000491183
  • ENST00000639252
  • ENSP00000491248
  • ENST00000639313
  • ENSP00000491707
  • ENST00000640782
  • ENSP00000491436

Symbol
  • CD158K
  • NKAT4
  • 3DL2
  • p140
  • NKAT4
  • CD158K
  • NKAT-4
  • NKAT4B
  • KIR-3DL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.98
cell type or tissue
0.67
disease
0.64
tissue
0.52
biological term
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.68   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.68   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
32.1
1
1
0
1.3
32.1
1
1
0
1.3
32.1
1
1
0
1.3
32.1
1
1
0
1.3
32.1
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
32.1
0
1.3
32.1
0
1.3
32.1
0
1.3
32.1
0
1.3
32.1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43630-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (146)
1 – 10 of 146
FAM114A2
Tdark
Novelty: 0.40545319
p_int: 0.99999216
p_ni: 0.00000784
Score: 0.181
Data Source: BioPlex,STRINGDB
PDLIM4
Tbio
Novelty: 0.01308013
p_int: 0.999977533
p_ni: 1.3e-8
p_wrong: 0.000022454
Score: 0.277
Data Source: BioPlex,STRINGDB
FBXO38
Tbio
Novelty: 0.06588101
p_int: 0.999757116
p_ni: 0.000242761
p_wrong: 1.23e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
FAM172A
Tbio
Novelty: 0.1200899
p_int: 0.999751924
p_ni: 0.000247994
p_wrong: 8.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.997914618
p_ni: 0.002085379
p_wrong: 3e-9
Data Source: BioPlex
IVD
Tbio
Family: Enzyme
Novelty: 0.03203942
p_int: 0.995246662
p_ni: 0.004753338
Score: 0.204
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.990300148
p_ni: 0.009699852
Data Source: BioPlex
ATRIP
Tbio
Novelty: 0.01415267
p_int: 0.989198642
p_ni: 0.010799388
p_wrong: 0.00000197
Score: 0.175
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.974173584
p_ni: 0.024056856
p_wrong: 0.00176956
Data Source: BioPlex
CISD2
Tbio
Novelty: 0.01665752
p_int: 0.972205283
p_ni: 0.027794516
p_wrong: 2.01e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  318.68

PubMed score by year
PubTator Score  221.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer