Tbio KIR3DL1 Killer cell immunoglobulin-like receptor 3DL1

Protein Summary

Description

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43629
• O43473
• Q14946
• Q16541

Gene Name

• KIR3DL1

Ensembl ID

• ENST00000358178
• ENSP00000350901
• ENSG00000167633
• ENST00000391728
• ENSP00000375608
• ENST00000612668
• ENSP00000484488
• ENSG00000274036
• ENST00000616188
• ENSP00000484036
• ENSG00000275288
• ENST00000621353
• ENSP00000484972
• ENSG00000276423
• ENST00000639353
• ENSP00000492794
• ENSG00000284342
• ENST00000639813
• ENSP00000492173
• ENSG00000284426
• ENST00000640111
• ENSP00000491437
• ENST00000640788
• ENSP00000491550

Symbol

• CD158E
• NKAT3
• NKB1
• KIR
• NKB1
• NKAT3
• NKB1B
• NKAT-3
• CD158E1
• KIR3DL1/S1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.84
cell line	0.73
biological term	0.59
cell type or tissue	0.58
disease	0.54

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Killer Cell Immunoglobulin-like Receptor 3dl1

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 3dl1

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 3dl1

Protein / ... / Protease Inhibitor / Killer Cell Immunoglobulin-like Receptor 3dl1

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 3dl1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.06   (req: < 5)

Gene RIFs: 146   (req: <= 3)

Antibodies: 514   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.06   (req: >= 5)

Gene RIFs: 146   (req: > 3)

Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0