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Tchem
NAMPT
Nicotinamide phosphoribosyltransferase

Protein Summary
Description
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222553
  • ENSP00000222553
  • ENSG00000105835

Symbol
  • PBEF
  • PBEF1
  • VF
  • PBEF
  • PBEF1
  • VISFATIN
  • 1110035O14Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
0.98
virus perturbation
0.97
transcription factor binding site profile
0.86
biological process
0.83


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.73   (req: < 5)
Gene RIFs: 425   (req: <= 3)
Antibodies: 885   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.73   (req: >= 5)
Gene RIFs: 425   (req: > 3)
Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2067
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nicotinamide phosphoribosyltransferase
698609
Mouse
MGI:1929865
59027
Rat
RGD:631365
297508
Dog
nicotinamide phosphoribosyltransferase
VGNC:49876
100856598
Horse
nicotinamide phosphoribosyltransferase
VGNC:20554
100059684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nicotinamide phosphoribosyltransferase
Mouse
Rat
Dog
nicotinamide phosphoribosyltransferase
Horse
nicotinamide phosphoribosyltransferase
Protein Structure (62 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43490-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 62
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (148)
1 – 10 of 148
LGALS7
Tbio
Novelty: 0.00753996
p_int: 0.99185746
p_ni: 0.00814254
Score: 0.169
Data Source: BioPlex,STRINGDB
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.958877994
p_ni: 0.041122006
Score: 0.159
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.931216274
p_ni: 0.068783726
Data Source: BioPlex
MAPK15
Tchem
Family: Kinase
Novelty: 0.02414054
p_int: 0.899314463
p_ni: 0.100685537
Score: 0.329
Data Source: BioPlex,STRINGDB
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.835208243
p_ni: 0.164791757
Score: 0.165
Data Source: BioPlex,STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
Score: 0.979
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
Score: 0.978
Data Source: STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.03261313
Score: 0.971
Data Source: STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
Score: 0.969
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.01709189
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  1383.73

PubMed score by year
PubTator Score  1095.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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