Tchem NAMPT Nicotinamide phosphoribosyltransferase

Protein Summary

Description

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P43490
• A4D0Q9
• A4D0R0
• Q3KQV0
• Q8WW95
• NAmPRTase

Gene Name

• NAMPT

Ensembl ID

• ENST00000222553
• ENSP00000222553
• ENSG00000105835

Symbol

• PBEF
• PBEF1
• VF
• PBEF
• PBEF1
• VISFATIN
• 1110035O14Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
transcription factor perturbation	0.98
virus perturbation	0.97
transcription factor binding site profile	0.86
biological process	0.83

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Nicotinamide Phosphoribosyltransferase

DTO Classes

Protein / Signaling / Cytokine / Nicotinamide Phosphoribosyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1604.45   (req: < 5)

Gene RIFs: 542   (req: <= 3)

Antibodies: 885   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1604.45   (req: >= 5)

Gene RIFs: 542   (req: > 3)

Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2183

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0