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Tchem
TNFRSF4
Tumor necrosis factor receptor superfamily member 4

Protein Summary
Description
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379236
  • ENSP00000368538
  • ENSG00000186827

Symbol
  • TXGP1L
  • OX40
  • ACT35
  • CD134
  • IMD16
  • TXGP1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
biological process
0.89
biological term
0.73
cell type or tissue
0.69
gene perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.06   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 773   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.06   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (140)
TNFSF4
Tbio
Novelty:  0.00308925
Score:  0.999
Data Source:  Reactome,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.907
Data Source:  STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.876
Data Source:  STRINGDB
TNFRSF18
Tbio
Novelty:  0.00374323
Score:  0.857
Data Source:  STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.845
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.831
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.827
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.794
Data Source:  STRINGDB
TRAF5
Tbio
Novelty:  0.01238512
Score:  0.785
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.781
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
3
3
87
2
1
0
1.1
67.9
1
1
0
1.1
44.6
urate measurement
2
1
2
18.3
blood protein measurement
1
1
1
16.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
87
0
1.1
67.9
0
1.1
44.6
urate measurement
2
18.3
blood protein measurement
1
16.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104512
22163
Rat
RGD:3920
25572
Dog
TNF receptor superfamily member 4
VGNC:47665
489600
Horse
TNF receptor superfamily member 4
VGNC:24372
100066167
Cow
TNF receptor superfamily member 4
VGNC:36168
528782
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TNF receptor superfamily member 4
Horse
TNF receptor superfamily member 4
Cow
TNF receptor superfamily member 4
Publication Statistics
PubMed Score 580.06
PubMed score by year
PubTator Score 228.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title