Tbio RANBP1 Ran-specific GTPase-activating protein

Protein Summary

Description

Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957). This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P43487
• Q53EY3

Gene Name

• RANBP1

Ensembl ID

• ENST00000331821
• ENSP00000327583
• ENSG00000099901
• ENST00000402752
• ENSP00000384925

Symbol

• HTF9A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
kinase perturbation	0.84
transcription factor	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ran-specific Gtpase-activating Protein

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ran-specific Gtpase-activating Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.89   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 252   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.89   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0