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Tclin
SYK
Tyrosine-protein kinase SYK

Protein Summary
Description
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375746
  • ENSP00000364898
  • ENSG00000165025
  • ENST00000375747
  • ENSP00000364899
  • ENST00000375751
  • ENSP00000364904
  • ENST00000375754
  • ENSP00000364907

Symbol
  • p72-Syk
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
biological term
0.99


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1814.39   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 1438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1814.39   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 1438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1363
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
fostamatinib
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.2
70.8
monocyte count
1
1
1
64.5
mean corpuscular volume
1
1
1
27
platelet crit
1
1
1
19.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
70.8
monocyte count
1
64.5
mean corpuscular volume
1
27
platelet crit
1
19.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spleen associated tyrosine kinase
VGNC:13975
464586
Macaque
spleen associated tyrosine kinase
704102
Mouse
MGI:99515
20963
Rat
RGD:3796
25155
Dog
spleen associated tyrosine kinase
VGNC:47021
484196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spleen associated tyrosine kinase
Macaque
spleen associated tyrosine kinase
Mouse
Rat
Dog
spleen associated tyrosine kinase
Protein Structure (70 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43405-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 70
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (80)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Gene Ontology Terms (78)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (446)
1 – 10 of 446
VAV1
Tchem
Novelty: 0.00180518
Score: 0.999
Data Source: Reactome,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.998
Data Source: Reactome,STRINGDB
BLNK
Tbio
Novelty: 0.00351169
Score: 0.997
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.994
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.993
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.991
Data Source: Reactome,STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.99
Data Source: Reactome,STRINGDB
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.988
Data Source: Reactome,STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.988
Data Source: Reactome,STRINGDB
CLEC7A
Tbio
Novelty: 0.00162014
Score: 0.988
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1814.39

PubMed score by year
PubTator Score  1083.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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