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Tchem
ZAP70
Tyrosine-protein kinase ZAP-70

Protein Summary
Description
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264972
  • ENSP00000264972
  • ENSG00000115085
  • ENST00000451498
  • ENSP00000400475

Symbol
  • SRK
  • SRK
  • STD
  • TZK
  • STCD
  • IMD48
  • ADMIO2
  • ZAP-70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological term
0.97
molecular function
0.96
hub protein
0.95
biological process
0.9


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 842.62   (req: < 5)
Gene RIFs: 190   (req: <= 3)
Antibodies: 2035   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 842.62   (req: >= 5)
Gene RIFs: 190   (req: > 3)
Antibodies: 2035   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
1
4
93.7
self reported educational attainment
1
1
1
77.2
diastolic blood pressure
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
93.7
self reported educational attainment
1
77.2
diastolic blood pressure
1
6.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zeta chain of T cell receptor associated protein kinase 70
VGNC:2916
459427
Macaque
tyrosine-protein kinase ZAP-70
707555
Mouse
MGI:99613
22637
Rat
RGD:3983
301348
Dog
zeta chain of T cell receptor associated protein kinase 70
VGNC:54555
100271860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zeta chain of T cell receptor associated protein kinase 70
Macaque
tyrosine-protein kinase ZAP-70
Mouse
Rat
Dog
zeta chain of T cell receptor associated protein kinase 70
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43403-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Generation of second messenger molecules
Reactome
Immune System
Reactome
TCR signaling
Reactome
Translocation of ZAP-70 to Immunological synapse
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Generation of second messenger molecules
Immune System
TCR signaling
Translocation of ZAP-70 to Immunological synapse
Protein-Protein Interactions (325)
1 – 10 of 325
LCP2
Tbio
Novelty: 0.00512968
Score: 0.998
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.998
Data Source: STRINGDB
CD247
Tbio
Novelty: 0.00217194
Score: 0.998
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.996
Data Source: STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.995
Data Source: Reactome,STRINGDB
CBLB
Tbio
Family: Enzyme
Novelty: 0.08068177
Score: 0.995
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.99
Data Source: Reactome,STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.99
Data Source: Reactome,STRINGDB
GRAP2
Tbio
Novelty: 0.00503901
Score: 0.988
Data Source: Reactome,STRINGDB
PTPN22
Tchem
Family: Enzyme
Novelty: 0.00168847
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  842.62

PubMed score by year
PubTator Score  1234.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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