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Tchem
PTPN9
Tyrosine-protein phosphatase non-receptor type 9

Protein Summary
Description
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618819
  • ENSP00000482732
  • ENSG00000169410

Symbol
  • MEG2
  • PTPMEG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.88
protein domain
0.85
interacting protein
0.82
microRNA
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.86   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.86   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
90.8
testosterone measurement
2
1
2
84.8
body height
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
90.8
testosterone measurement
2
84.8
body height
2
83
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 9
VGNC:2471
737244
Macaque
protein tyrosine phosphatase, non-receptor type 9
705974
Mouse
MGI:1928376
56294
Rat
RGD:628726
266611
Dog
protein tyrosine phosphatase, non-receptor type 9
VGNC:45181
612991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 9
Macaque
protein tyrosine phosphatase, non-receptor type 9
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 9
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43378-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Signaling by Interleukins
Protein-Protein Interactions (46)
1 – 10 of 46
EYA1
Tbio
Novelty: 0.00585286
p_int: 0.999986856
p_ni: 0.000013144
Score: 0.335
Data Source: BioPlex,STRINGDB
RAD51C
Tbio
Novelty: 0.0063568
p_int: 0.999060315
p_ni: 0.000939685
Score: 0.188
Data Source: BioPlex,STRINGDB
CALHM4
Tdark
Family: IC
Novelty: 2.79788039
p_int: 0.998602119
p_ni: 0.001397831
p_wrong: 5e-8
Data Source: BioPlex
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.990660754
p_ni: 0.009339246
Data Source: BioPlex
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.981733674
p_ni: 0.018266326
Score: 0.155
Data Source: BioPlex,STRINGDB
MDK
Tchem
Novelty: 0.00145301
p_int: 0.910301007
p_ni: 0.089698993
Score: 0.186
Data Source: BioPlex,STRINGDB
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.895124098
p_ni: 0.104875589
p_wrong: 3.13e-7
Data Source: BioPlex
SEC14L1
Tbio
Novelty: 0.09562071
Score: 0.905
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.902
Data Source: STRINGDB
IL37
Tbio
Novelty: 0.00499186
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.86

PubMed score by year
PubTator Score  25.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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