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Tbio
MAGEA4
Melanoma-associated antigen 4

Protein Summary
Description
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276344
  • ENSP00000276344
  • ENSG00000147381
  • ENST00000360243
  • ENSP00000353379
  • ENST00000370335
  • ENSP00000359360
  • ENST00000370340
  • ENSP00000359365
  • ENST00000393920
  • ENSP00000377497
  • ENST00000393921
  • ENSP00000377498

Symbol
  • MAGE4
  • CT1.4
  • MAGE4
  • MAGE4A
  • MAGE4B
  • MAGE-41
  • MAGE-X2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
transcription factor
0.51
biological term
0.48
cell line
0.48
microRNA
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.45   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.45   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (84)
1 – 10 of 84
MAGEA10
Tbio
Novelty: 0.0518709
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.599
Data Source: BioPlex,STRINGDB
TSPYL4
Tdark
Novelty: 0.64864865
p_int: 0.999999796
p_ni: 1.87e-7
p_wrong: 1.6e-8
Score: 0.663
Data Source: BioPlex,STRINGDB
PPP1R13L
Tbio
Novelty: 0.01551275
p_int: 0.999999726
p_ni: 2.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
MAGEA9
Tbio
Novelty: 0.05648387
p_int: 0.999999603
p_ni: 4e-9
p_wrong: 3.93e-7
Data Source: BioPlex
MAGEB16
Tdark
Novelty: 0.26373626
p_int: 0.999998916
p_wrong: 0.000001084
Score: 0.294
Data Source: BioPlex,STRINGDB
MDM1
Tbio
Novelty: 0.05983444
p_int: 0.999998849
p_ni: 2.9e-8
p_wrong: 0.000001122
Score: 0.261
Data Source: BioPlex,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00575302
p_int: 0.999994381
p_ni: 0.000005619
Score: 0.305
Data Source: BioPlex,STRINGDB
UQCRB
Tbio
Novelty: 0.04413786
p_int: 0.999930193
p_ni: 0.000069807
Score: 0.234
Data Source: BioPlex,STRINGDB
TIGD5
Tdark
Novelty: 2.52631579
p_int: 0.99975571
p_ni: 0.00024429
Score: 0.224
Data Source: BioPlex,STRINGDB
CCDC85B
Tdark
Novelty: 0.01424139
p_int: 0.999308648
p_ni: 0.000689105
p_wrong: 0.000002247
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  108.45

PubMed score by year
PubTator Score  120.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer