Tbio MAGEA4 Melanoma-associated antigen 4

Protein Summary

Description

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43358
• Q14798

Gene Name

• MAGEA4

Ensembl ID

• ENST00000276344
• ENSP00000276344
• ENSG00000147381
• ENST00000360243
• ENSP00000353379
• ENST00000370335
• ENSP00000359360
• ENST00000370340
• ENSP00000359365
• ENST00000393920
• ENSP00000377497
• ENST00000393921
• ENSP00000377498

Symbol

• MAGE4
• CT1.4
• MAGE4
• MAGE4A
• MAGE4B
• MAGE-41
• MAGE-X2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
transcription factor	0.51
biological term	0.48
cell line	0.48
microRNA	0.47

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen 4

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.63   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 327   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.63   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0