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Tbio
MAGEA4
Melanoma-associated antigen 4

Protein Summary
Description
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276344
  • ENSP00000276344
  • ENSG00000147381
  • ENST00000360243
  • ENSP00000353379
  • ENST00000370335
  • ENSP00000359360
  • ENST00000370340
  • ENSP00000359365
  • ENST00000393920
  • ENSP00000377497
  • ENST00000393921
  • ENSP00000377498

Symbol
  • MAGE4
  • CT1.4
  • MAGE4
  • MAGE4A
  • MAGE4B
  • MAGE-41
  • MAGE-X2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
transcription factor
0.51
biological term
0.48
cell line
0.48
microRNA
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43358-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (84)
1 – 10 of 84
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.599
Data Source: BioPlex,STRINGDB
TSPYL4
Tdark
Novelty: 0.4538252
p_int: 0.999999796
p_ni: 1.87e-7
p_wrong: 1.6e-8
Score: 0.663
Data Source: BioPlex,STRINGDB
PPP1R13L
Tbio
Novelty: 0.01378765
p_int: 0.999999726
p_ni: 2.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
MAGEA9
Tbio
Novelty: 0.07926412
p_int: 0.999999603
p_ni: 4e-9
p_wrong: 3.93e-7
Data Source: BioPlex
MAGEB16
Tdark
Novelty: 0.4467116
p_int: 0.999998916
p_wrong: 0.000001084
Score: 0.294
Data Source: BioPlex,STRINGDB
MDM1
Tbio
Novelty: 0.05542886
p_int: 0.999998849
p_ni: 2.9e-8
p_wrong: 0.000001122
Score: 0.261
Data Source: BioPlex,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
p_int: 0.999994381
p_ni: 0.000005619
Score: 0.305
Data Source: BioPlex,STRINGDB
UQCRB
Tbio
Novelty: 0.02933046
p_int: 0.999930193
p_ni: 0.000069807
Score: 0.234
Data Source: BioPlex,STRINGDB
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.99975571
p_ni: 0.00024429
Score: 0.224
Data Source: BioPlex,STRINGDB
CCDC85B
Tdark
Novelty: 0.02034018
p_int: 0.999308648
p_ni: 0.000689105
p_wrong: 0.000002247
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  112.32

PubMed score by year
PubTator Score  120.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer