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Tbio
MAGEA2
Melanoma-associated antigen 2

Protein Summary
Description
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331220
  • ENSP00000333487
  • ENSG00000183305
  • ENST00000370293
  • ENSP00000359316
  • ENST00000595583
  • ENSP00000470872
  • ENSG00000268606
  • ENST00000598543
  • ENSP00000469919
  • ENST00000611557
  • ENSP00000480738
  • ENST00000611674
  • ENSP00000480491
  • ENST00000620710
  • ENSP00000484290
  • ENST00000623438
  • ENSP00000485391
  • ENST00000623806
  • ENSP00000485541

Symbol
  • MAGE2
  • MAGEA2A
  • CT1.2
  • MAGE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cellular component
0.54
chemical
0.41
cell line
0.4
biological term
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0