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Tbio
MAGEA1
Melanoma-associated antigen 1

Protein Summary
Description
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356661
  • ENSP00000349085
  • ENSG00000198681

Symbol
  • MAGE1
  • MAGE1A
  • CT1.1
  • MAGE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
biological process
0.58
biological term
0.52
tissue sample
0.49
chemical
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.21   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.21   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (158)
1 – 10 of 158
HSPBAP1
Tbio
Novelty: 0.03321047
p_int: 0.99999999
p_ni: 5e-9
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
SPAG1
Tbio
Novelty: 0.01839474
p_int: 0.999999815
p_ni: 1.62e-7
p_wrong: 2.3e-8
Score: 0.226
Data Source: BioPlex,STRINGDB
ANKRD17
Tbio
Novelty: 0.03177323
p_int: 0.999999487
p_ni: 5.13e-7
Data Source: BioPlex
CCDC14
Tdark
Novelty: 0.62617082
p_int: 0.999999451
p_ni: 5.49e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.999998549
p_ni: 0.00000137
p_wrong: 8.2e-8
Data Source: BioPlex
ANKHD1
Tbio
Novelty: 0.05390096
p_int: 0.999998298
p_ni: 0.000001702
Data Source: BioPlex
MAGEA9
Tbio
Novelty: 0.07926412
p_int: 0.999996987
p_ni: 0.000003013
Score: 0.195
Data Source: BioPlex,STRINGDB
CCDC102A
Tdark
Novelty: 1.89784272
p_int: 0.999996966
p_ni: 0.000003034
Data Source: BioPlex
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.999991164
p_ni: 0.000008835
p_wrong: 2e-9
Data Source: BioPlex
NAP1L3
Tbio
Novelty: 0.03907508
p_int: 0.999986445
p_ni: 0.000012786
p_wrong: 7.68e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  201.21

PubMed score by year
PubTator Score  184.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer