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Tchem
NR4A2
Nuclear receptor subfamily 4 group A member 2

Protein Summary
Description
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339562
  • ENSP00000344479
  • ENSG00000153234
  • ENST00000409572
  • ENSP00000386747
  • ENST00000426264
  • ENSP00000389986

Symbol
  • NOT
  • NURR1
  • TINUR
  • NOT
  • RNR1
  • HZF-3
  • NURR1
  • TINUR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.99
molecular function
0.97
PubMedID
0.97
biological process
0.95
transcription factor binding site profile
0.93


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.51   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.51   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 2
VGNC:2728
459669
Macaque
nuclear receptor subfamily 4 group A member 2
697077
Mouse
MGI:1352456
18227
Rat
RGD:3202
54278
Dog
nuclear receptor subfamily 4 group A member 2
VGNC:43955
478754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 2
Macaque
nuclear receptor subfamily 4 group A member 2
Mouse
Rat
Dog
nuclear receptor subfamily 4 group A member 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43354-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (167)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Nuclear Receptor transcription pathway
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Nuclear Receptor transcription pathway
Post-translational protein modification
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Protein-Protein Interactions (141)
1 – 10 of 141
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.946
Data Source: Reactome,STRINGDB
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
Score: 0.945
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.912
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.91
Data Source: Reactome,STRINGDB
SUMO3
Tbio
Novelty: 0.03096465
Score: 0.9
Data Source: Reactome,STRINGDB
PITX3
Tbio
Family: TF
Novelty: 0.00579075
Score: 0.893
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.87
Data Source: STRINGDB
LMX1A
Tbio
Family: TF
Novelty: 0.0104588
Score: 0.87
Data Source: STRINGDB
FOSB
Tbio
Family: TF
Novelty: 0.00183071
Score: 0.867
Data Source: STRINGDB
LMX1B
Tbio
Family: TF
Novelty: 0.00405645
Score: 0.825
Data Source: STRINGDB
Publication Statistics
PubMed Score  558.51

PubMed score by year
PubTator Score  297.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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