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Tbio
ALDH3B1
Aldehyde dehydrogenase family 3 member B1

Protein Summary
Description
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342456
  • ENSP00000473990
  • ENSG00000006534
  • ENST00000614849
  • ENSP00000478486
  • ENST00000617288
  • ENSP00000481604

Symbol
  • ALDH7
  • ALDH4
  • ALDH7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor
0.77
pathway
0.67
microRNA
0.6
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.82   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.82   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
CHIT1
Tchem
Family:  Enzyme
Novelty:  0.00113383
p_int:  0.99999994
p_ni:  6e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
ALDH3B2
Tbio
Family:  Enzyme
Novelty:  0.08791168
p_int:  0.999999534
p_ni:  4.66e-7
Score:  0.591
Data Source:  BioPlex,STRINGDB
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.999998975
p_ni:  6.99e-7
p_wrong:  3.27e-7
Data Source:  BioPlex
FMN2
Tbio
Novelty:  0.02031944
p_int:  0.998572962
p_ni:  0.001427037
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.993487964
p_ni:  0.006375697
p_wrong:  0.000136339
Data Source:  BioPlex
WDR73
Tbio
Novelty:  0.10253438
p_int:  0.991496027
p_ni:  0.008503391
p_wrong:  5.82e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
SELENOT
Tbio
Novelty:  0.02480242
p_int:  0.944066885
p_ni:  0.055929069
p_wrong:  0.000004046
Score:  0.217
Data Source:  BioPlex,STRINGDB
UBA6
Tchem
Novelty:  0.05213412
p_int:  0.936657745
p_ni:  0.063341859
p_wrong:  3.96e-7
Score:  0.198
Data Source:  BioPlex,STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
p_int:  0.927314777
p_ni:  0.072685223
Score:  0.187
Data Source:  BioPlex,STRINGDB
IREB2
Tbio
Novelty:  0.00300491
p_int:  0.91894014
p_ni:  0.046052248
p_wrong:  0.035007613
Score:  0.222
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
Pathways (25)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
66.6
serum non-albumin protein measurement
1
1
1
55.2
reticulocyte count
1
1
1
40.7
serum albumin measurement
1
1
1
33.1
BMI-adjusted waist circumference
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
66.6
serum non-albumin protein measurement
1
55.2
reticulocyte count
1
40.7
serum albumin measurement
1
33.1
BMI-adjusted waist circumference
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
aldehyde dehydrogenase 3 family member B1
710746
Mouse
MGI:1914939
67689
Rat
RGD:1359546
309147
Horse
aldehyde dehydrogenase 3 family member B1
100053339
Cow
aldehyde dehydrogenase 3 family member B1
511469
Species
Name
OMA
EggNOG
Inparanoid
Macaque
aldehyde dehydrogenase 3 family member B1
Mouse
Rat
Horse
aldehyde dehydrogenase 3 family member B1
Cow
aldehyde dehydrogenase 3 family member B1
Publication Statistics
PubMed Score 26.82
PubMed score by year
PubTator Score 13.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title