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Tbio
RAD52
DNA repair protein RAD52 homolog

Protein Summary
Description
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358495
  • ENSP00000351284
  • ENSG00000002016
  • ENST00000430095
  • ENSP00000387901
  • ENST00000461568
  • ENSP00000436008
  • ENST00000468231
  • ENSP00000434703
  • ENST00000541619
  • ENSP00000438965
  • ENST00000544742
  • ENSP00000443254
  • ENST00000545564
  • ENSP00000440268
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.88
transcription factor binding site profile
0.86
histone modification site profile
0.83
tissue
0.63
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 817.3   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 817.3   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
47.5
systolic blood pressure
1
1
1
39.3
eosinophil percentage of granulocytes
1
1
1
23.2
reticulocyte measurement
2
1
2
22.3
neutrophil percentage of granulocytes
1
1
1
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
47.5
systolic blood pressure
1
39.3
eosinophil percentage of granulocytes
1
23.2
reticulocyte measurement
2
22.3
neutrophil percentage of granulocytes
1
17.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD52 homolog, DNA repair protein
VGNC:5563
466911
Macaque
RAD52 homolog (S. cerevisiae)
100426645
Mouse
MGI:101949
19365
Rat
RGD:1304975
297561
Dog
RAD52 homolog, DNA repair protein
VGNC:45321
477729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD52 homolog, DNA repair protein
Macaque
RAD52 homolog (S. cerevisiae)
Mouse
Rat
Dog
RAD52 homolog, DNA repair protein
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43351-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
HDR through Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
HDR through Single Strand Annealing (SSA)
Homology Directed Repair
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (250)
1 – 10 of 250
RPA2
Tbio
Novelty: 0.00879115
Score: 0.999
Data Source: STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.999
Data Source: Reactome,STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: STRINGDB
RPA3
Tbio
Novelty: 0.00887858
Score: 0.999
Data Source: STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.996
Data Source: STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.995
Data Source: STRINGDB
WRN
Tbio
Family: Enzyme
Novelty: 0.00163164
Score: 0.994
Data Source: STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.993
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.992
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  817.30

PubMed score by year
PubTator Score  185.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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