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Tbio
CRYBB2
Beta-crystallin B2

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398215
  • ENSP00000381273
  • ENSG00000244752

Symbol
  • CRYB2
  • CRYB2A
  • CCA2
  • CRYB2
  • CRYB2A
  • CTRCT3
  • D22S665
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
gene perturbation
0.65
cell type or tissue
0.62
disease perturbation
0.56
cellular component
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.39   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.39   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
crystallin beta B2
100144420
Mouse
MGI:88519
12961
Rat
RGD:2417
25422
Dog
crystallin beta B2
VGNC:39640
486326
Horse
crystallin beta B2
VGNC:16886
100059550
Species
Name
OMA
EggNOG
Inparanoid
Macaque
crystallin beta B2
Mouse
Rat
Dog
crystallin beta B2
Horse
crystallin beta B2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43320-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (45)
1 – 10 of 45
CRYAA
Tbio
Novelty: 0.01914081
Score: 0.945
Data Source: STRINGDB
CRYAA2
Tdark
Novelty: 0.01914081
Score: 0.934
Data Source: STRINGDB
GJA3
Tbio
Novelty: 0.00638283
Score: 0.921
Data Source: STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
Score: 0.903
Data Source: STRINGDB
CRYBB3
Tbio
Novelty: 0.0455879
Score: 0.816
Data Source: STRINGDB
GJA8
Tbio
Novelty: 0.00377739
Score: 0.814
Data Source: STRINGDB
BFSP2
Tbio
Novelty: 0.00206411
Score: 0.812
Data Source: STRINGDB
HSF4
Tbio
Family: TF
Novelty: 0.01736563
Score: 0.81
Data Source: STRINGDB
MIP
Tbio
Novelty: 0.00299543
Score: 0.767
Data Source: STRINGDB
TMEM114
Tdark
Novelty: 0.25895358
Score: 0.744
Data Source: STRINGDB
Publication Statistics
PubMed Score  145.39

PubMed score by year
PubTator Score  118.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer