Tbio SSR2 Translocon-associated protein subunit beta

Protein Summary

Description

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43308
• B2R9K9
• D3DVA7
• Q53HI0
• Q5VY95
• Q5VY96
• Q6IB31
• Q9BWE4
• TRAP-beta

Gene Name

• SSR2

Ensembl ID

• ENST00000295702
• ENSP00000295702
• ENSG00000163479
• ENST00000480567
• ENSP00000434306

Symbol

• TRAPB
• TLAP
• HSD25
• TRAPB
• TRAP-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.96
virus perturbation	0.85
histone modification site profile	0.81
co-expressed gene	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.8   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.8   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0