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Tbio
SSR2
Translocon-associated protein subunit beta

Protein Summary
Description
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295702
  • ENSP00000295702
  • ENSG00000163479
  • ENST00000480567
  • ENSP00000434306

Symbol
  • TRAPB
  • TLAP
  • HSD25
  • TRAPB
  • TRAP-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.96
virus perturbation
0.85
histone modification site profile
0.81
co-expressed gene
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
87.8
body height
1
1
1
71.6
appendicular lean mass
3
2
4
68.2
myeloid white cell count
2
2
2
63.4
neutrophil count
2
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
87.8
body height
1
71.6
appendicular lean mass
4
68.2
myeloid white cell count
2
63.4
neutrophil count
2
63
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 2
VGNC:10420
457379
Macaque
signal sequence receptor subunit 2
719383
Mouse
MGI:1913506
66256
Rat
RGD:1308365
295235
Dog
signal sequence receptor subunit 2
VGNC:46838
403950
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 2
Macaque
signal sequence receptor subunit 2
Mouse
Rat
Dog
signal sequence receptor subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43308-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Protein-Protein Interactions (158)
1 – 10 of 158
SSR3
Tbio
Novelty:  0.05838475
Score:  0.998
Data Source:  Reactome,STRINGDB
SSR1
Tbio
Novelty:  0.02009694
Score:  0.998
Data Source:  Reactome,STRINGDB
SSR4
Tbio
Novelty:  0.04072695
Score:  0.997
Data Source:  Reactome,STRINGDB
TRAM1
Tbio
Novelty:  0.17795822
Score:  0.996
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.996
Data Source:  STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
Score:  0.99
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.989
Data Source:  STRINGDB
SEC61A2
Tdark
Novelty:  1.46395791
Score:  0.977
Data Source:  STRINGDB
SEC11A
Tbio
Family:  Enzyme
Novelty:  0.05764568
Score:  0.973
Data Source:  STRINGDB
SPCS3
Tbio
Family:  Enzyme
Novelty:  0.13677259
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  72.78

PubMed score by year
PubTator Score  29.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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