Tbio SSR1 Translocon-associated protein subunit alpha

Protein Summary

Description

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P43307
• A8K685
• Q53GX2
• Q53H19
• Q5TAM3
• Q6IB43
• Q8NBH9
• Q96IA2
• Q9TNQ8
• Q9UN49
• TRAP-alpha

Gene Name

• SSR1

Ensembl ID

• ENST00000244763
• ENSP00000244763
• ENSG00000124783

Symbol

• TRAPA
• TRAPA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	1
disease perturbation	0.96
virus perturbation	0.96
interacting protein	0.94

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Translocon-associated Protein Subunit Alpha

Protein / Calcium-binding Protein / Translocon-associated Protein Subunit Alpha

DTO Classes

Protein / Calcium-binding Protein / Translocon-associated Protein Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.48   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.48   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0