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Tbio
SSR1
Translocon-associated protein subunit alpha

Protein Summary
Description
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
disease perturbation
0.96
virus perturbation
0.96
interacting protein
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
3
3
95.6
hemoglobin measurement
2
3
3
94.7
12
5
4
1.1
94.4
HbA1c measurement
2
3
3
92.4
heel bone mineral density
3
2
5
91.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
95.6
hemoglobin measurement
3
94.7
4
1.1
94.4
HbA1c measurement
3
92.4
heel bone mineral density
5
91.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 1
VGNC:12704
100614603
Macaque
signal sequence receptor subunit 1
693818
Mouse
MGI:105082
107513
Rat
RGD:1310961
361233
Dog
signal sequence receptor subunit 1
VGNC:46837
403951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 1
Macaque
signal sequence receptor subunit 1
Mouse
Rat
Dog
signal sequence receptor subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43307-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Unfolded Protein Response (UPR)
Protein-Protein Interactions (176)
1 – 10 of 176
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.798915217
p_ni:  0.201084783
Score:  0.211
Data Source:  BioPlex,STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
p_int:  0.768571323
p_ni:  0.231428677
Data Source:  BioPlex
SSR3
Tbio
Novelty:  0.05838475
Score:  0.999
Data Source:  Reactome,STRINGDB
SSR2
Tbio
Novelty:  0.01383689
Score:  0.998
Data Source:  Reactome,STRINGDB
SSR4
Tbio
Novelty:  0.04072695
Score:  0.995
Data Source:  Reactome,STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.989
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.985
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.984
Data Source:  STRINGDB
SEC61A2
Tdark
Novelty:  1.46395791
Score:  0.981
Data Source:  STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
Score:  0.964
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.95

PubMed score by year
PubTator Score  52.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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