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Tbio
GPD2
Glycerol-3-phosphate dehydrogenase, mitochondrial

Protein Summary
Description
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310454
  • ENSP00000308610
  • ENSG00000115159
  • ENST00000409125
  • ENSP00000386484
  • ENST00000409674
  • ENSP00000386425
  • ENST00000409861
  • ENSP00000386626
  • ENST00000438166
  • ENSP00000409708

Symbol
  • GDH2
  • GPDM
  • mGPDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.88
disease perturbation
0.87
trait
0.86
microRNA
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.45   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.45   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
5
3
6
93.9
refractive error measurement
2
2
1
7.8
88.4
1
1
1
83.4
Myopia
2
2
0
4.4
66.1
age at onset
1
1
0
7.8
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
6
93.9
refractive error measurement
1
7.8
88.4
1
83.4
Myopia
0
4.4
66.1
age at onset
0
7.8
51.2
Pathways (15)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (151)
1 – 10 of 151
LIX1L
Tdark
Novelty: 0.5277858
p_int: 0.999997933
p_ni: 0.000001983
p_wrong: 8.4e-8
Data Source: BioPlex
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
p_int: 0.999938094
p_ni: 0.000061906
Score: 0.374
Data Source: BioPlex,STRINGDB
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.999917304
p_ni: 0.000082696
Data Source: BioPlex
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
p_int: 0.999583437
p_ni: 0.000416563
Data Source: BioPlex
TGFA
Tbio
Novelty: 0.00216159
p_int: 0.999479008
p_ni: 0.00052099
p_wrong: 3e-9
Data Source: BioPlex
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.999214165
p_ni: 0.000785834
Data Source: BioPlex
TRAPPC10
Tbio
Novelty: 0.03433058
p_int: 0.997923883
p_ni: 0.002076117
Score: 0.234
Data Source: BioPlex,STRINGDB
SLC8A3
Tchem
Family: Transporter
Novelty: 0.01041945
p_int: 0.992746129
p_ni: 0.007253871
Score: 0.204
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.981602066
p_ni: 0.018397934
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.978404599
p_ni: 0.021595401
Data Source: BioPlex
Publication Statistics
PubMed Score  103.45

PubMed score by year
PubTator Score  42.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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