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Tbio
ETV4
ETS translocation variant 4

Protein Summary
Description
Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319349
  • ENSP00000321835
  • ENSG00000175832
  • ENST00000393664
  • ENSP00000377273
  • ENST00000538265
  • ENSP00000443846
  • ENST00000545954
  • ENSP00000440023
  • ENST00000586826
  • ENSP00000468636
  • ENST00000591713
  • ENSP00000465718

Symbol
  • E1AF
  • PEA3
  • E1AF
  • PEA3
  • E1A-F
  • PEAS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
gene perturbation
0.9
kinase perturbation
0.88
transcription factor binding site profile
0.8
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.16   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.16   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Signal Transduction
Protein-Protein Interactions (95)
1 – 10 of 95
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.83872678
p_ni: 0.16127322
Score: 0.453
Data Source: BioPlex,STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.967
Data Source: Reactome,STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.961
Data Source: STRINGDB
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
Score: 0.922
Data Source: STRINGDB
EWSR1
Tbio
Novelty: 0.00068411
Score: 0.793
Data Source: STRINGDB
FGF10
Tbio
Novelty: 0.00217451
Score: 0.746
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.728
Data Source: STRINGDB
FGF3
Tbio
Novelty: 0.00474087
Score: 0.727
Data Source: STRINGDB
TMPRSS2
Tchem
Family: Enzyme
Novelty: 0.00117884
Score: 0.726
Data Source: STRINGDB
EPPIN
Tbio
Novelty: 0.02639469
Score: 0.711
Data Source: STRINGDB
Publication Statistics
PubMed Score  296.16

PubMed score by year
PubTator Score  164.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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